血清尿酸与代谢综合征的关系：结构方程模型分析。

Relationship between serum uric acid and metabolic syndrome: an analysis by structural equation modeling.

机构信息

Department of Health Statistics, School of Public Health, Tianjin Medical University, Tianjin, China.

出版信息

J Clin Lipidol. 2012 Mar-Apr;6(2):159-67. doi: 10.1016/j.jacl.2011.11.006. Epub 2011 Dec 4.

DOI:10.1016/j.jacl.2011.11.006

PMID:22385549

Abstract

OBJECTIVE

To investigate the nature of the relationships between uric acid and metabolic syndrome (MetS) components.

METHODS

Body mass index, waist circumference, serum uric acid, fasting glucose, lipid profiles, and blood pressure were measured in 13,811 subjects aged between 18 and 85 years of age. Two structural equation models (SEMs) were used to test a hypothesis regarding the linking roles of uric acid in the occurrence of MetS components in male and female separately.

RESULTS

The findings of the SEM demonstrated that increased uric acid level was associated with fasting glucose (beta = 0.221, P < .001), blood pressure (beta = 0.158, P < .001), and lipid profiles (beta = 0.391, P < .001) in women. Increased uric acid level was associated with decreased fasting glucose (beta = -0.071, P < .001) and increased lipid profiles (beta = 0.352, P < .001) in men. The association was stronger between uric acid and lipid profiles than those between uric acid and other MetS components.

CONCLUSION

By using SEM, we were able to confirm the intimate relationships between uric acid and MetS components, particularly in women. The associations between uric acid and MetS components were gender specific, and the nature of such association requires further exploration.

摘要

目的

探讨尿酸与代谢综合征（MetS）各组分之间关系的本质。

方法

在 13811 名年龄在 18 至 85 岁的受试者中测量了体重指数、腰围、血清尿酸、空腹血糖、血脂谱和血压。分别使用两种结构方程模型（SEMs）来检验尿酸在男性和女性中与 MetS 各组分发生的关联作用的假设。

结果

SEM 的研究结果表明，女性血尿酸水平升高与空腹血糖（β=0.221，P<0.001）、血压（β=0.158，P<0.001）和血脂谱（β=0.391，P<0.001）相关。男性血尿酸水平升高与空腹血糖降低（β=-0.071，P<0.001）和血脂谱升高（β=0.352，P<0.001）相关。尿酸与血脂谱之间的相关性强于尿酸与其他 MetS 组分之间的相关性。