Department of Psychology, Luther College, Decorah, IA 52101, USA.
Explore (NY). 2012 Mar-Apr;8(2):92-8. doi: 10.1016/j.explore.2011.12.003.
A novel mind-body approach (amygdala retraining) is hypothesized to improve symptoms related to fibromyalgia and chronic fatigue.
To examine the use of a mind-body approach for improving symptoms related to fibromyalgia and chronic fatigue.
This was a single-blind, randomized controlled trial.
The study was conducted in a tertiary-care fibromyalgia and chronic fatigue clinic.
Patients with fibromyalgia, chronic fatigue, or both were included.
Patients were randomly assigned to receive amygdala retraining along with standard care or standard care alone. Standard care involved attending a 1.5-day multidisciplinary program. The amygdala retraining group received an additional 2.5-hour training course in which the key tools and techniques adapted from an existing program were taught to the patient. A home-study video course and associated text were provided to supplement the on-site program. Both groups received telephone calls twice a month to answer questions related to technique and to provide support.
Validated self-report questionnaires related to general health, well-being, and symptoms, including Short Form-36, Measure Yourself Medical Outcome Profile, Multidimensional Fatigue Inventory, Epworth Sleepiness Scale, and Fibromyalgia Impact Questionnaire.
Of the 44 patients randomly assigned who completed baseline assessments, 21 patients completed the study (14 in the standard care group and 7 in the study group). Median age was 48 years (range, 27-56 years), and female subjects comprised 91% of the group. Analyses demonstrated statistically significant improvements in scores for physical health, energy, pain, symptom distress, and fatigue in patients who received the amygdala retraining compared with standard care.
一种新颖的心身方法（杏仁核再训练）被假设可以改善与纤维肌痛和慢性疲劳相关的症状。
研究一种心身方法对改善纤维肌痛和慢性疲劳相关症状的效果。
这是一项单盲、随机对照试验。
研究在一家三级护理纤维肌痛和慢性疲劳诊所进行。
纳入患有纤维肌痛、慢性疲劳或两者兼有患者。
患者被随机分配接受杏仁核再训练联合标准护理或仅接受标准护理。标准护理包括参加为期 1.5 天的多学科计划。杏仁核再训练组额外接受 2.5 小时的培训课程，向患者传授从现有计划中改编的关键工具和技术。提供家庭学习视频课程和相关文本，以补充现场计划。两组均每月接受两次电话访问，以回答与技术相关的问题并提供支持。
使用与一般健康、幸福感和症状相关的有效自评问卷进行评估，包括简明健康状况调查问卷、健康测量自评量表、多维疲劳量表、艾普沃斯嗜睡量表和纤维肌痛影响问卷。
在完成基线评估的 44 名随机分配患者中，有 21 名完成了研究（标准护理组 14 名，研究组 7 名）。中位年龄为 48 岁（范围，27-56 岁），女性占 91%。分析表明，接受杏仁核再训练的患者在身体健康、能量、疼痛、症状困扰和疲劳方面的评分较标准护理显著改善。
