Hart S, Bareford D, Smith N, MacWhannel A, Lanchbury E, Boughton B
Vox Sang. 1990;59(2):123-4. doi: 10.1111/j.1423-0410.1990.tb05024.x.
Previous work in our department showed that after blood transfusion, the platelet count often falls to levels which are clinically significant. The probable site of platelet sequestration was identified as the spleen, and post-transfusion thrombocytopenia was prevented by blood filters which remove microaggregate debris from the donor blood. Since the duration of the thrombocytopenia has not been investigated, the purpose of the present study was to establish the rate of onset and duration of post-transfusion thrombocytopenia following packed red blood cell transfusions. In addition, the effect of spleen size, patients' diagnosis and post-transfusion history were examined. These observations provide interesting new data on the mechanisms involved in this phenomenon.
我们科室之前的研究表明，输血后血小板计数常常会降至具有临床意义的水平。血小板滞留的可能部位被确定为脾脏，并且通过能从供血中去除微聚集体碎片的血液滤器可预防输血后血小板减少症。由于尚未对血小板减少症的持续时间进行研究，本研究的目的是确定输注浓缩红细胞后输血后血小板减少症的发病速率和持续时间。此外，还研究了脾脏大小、患者诊断和输血后病史的影响。这些观察结果为这一现象所涉及的机制提供了有趣的新数据。
