Lim S, Boughton B J, Bareford D
Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
Vox Sang. 1989;56(1):40-1. doi: 10.1111/j.1423-0410.1989.tb03046.x.
11 patients with anaemia and thrombocytopenia due to bone marrow failure each received 2 sets of red-cell transfusions. They were randomised to receive 1 blood transfusion through a standard 170-micron giving set filter and another through a 40 micron micro-aggregate filter. After transfusion, the mean fall in platelet count was 15 x 10(9)/l (41.7%) and 1.4 x 10(9)/l (4.6%), respectively (p less than 0.01). The results confirm the findings of a previous study which showed that micro-aggregate filters prevent a post-transfusional decrease in platelet counts. In addition, this new study shows that this is clinically relevant in patients who are thrombocytopenic at the time of their blood transfusion.
11例因骨髓衰竭导致贫血和血小板减少的患者每人接受了2组红细胞输血。他们被随机分配，一组通过标准的170微米输血器过滤器接受输血，另一组通过40微米微聚体过滤器接受输血。输血后，血小板计数的平均下降分别为15×10⁹/L（41.7%）和1.4×10⁹/L（4.6%）（p<0.01）。这些结果证实了先前一项研究的发现，该研究表明微聚体过滤器可防止输血后血小板计数下降。此外，这项新研究表明，这在输血时血小板减少的患者中具有临床相关性。
