Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
J Clin Neurosci. 2012 May;19(5):753-6. doi: 10.1016/j.jocn.2011.09.019. Epub 2012 Mar 2.
Fibrinogen plays an important role in the intrinsic and extrinsic pathways of blood coagulation. This study investigated the association between common variants in the fibrinogen gene and the risk of developing sporadic cerebral hemorrhage (CH). We performed genotyping analyses for three single nucleotide polymorphisms (SNP) in the fibrinogen gene in a case-controlled study involving 195 patients with CH and 116 control participants; both groups were of southern Han-Chinese origin. Logistic regression analysis indicated that haplotypes ATA (rs1800790+rs1800787+rs6050), AA (rs1800790+rs6050) and TA (rs1800787+rs6050) could nearly double the risk of sporadic CH (odds ratio [OR]=1.738, 95% confidence interval [CI]: 1.103-2.740, p=0.017; adjusted OR=1.762, 95% CI: 1.042-2.982, p=0.035), although the three SNP were not associated with sporadic CH when analyzed separately. These findings indicate that rs1800790, rs1800787 and rs6050 polymorphisms may contribute to the etiology of sporadic CH in the Chinese population.
纤维蛋白原在血液凝血的内在和外在途径中起着重要作用。本研究探讨了纤维蛋白原基因常见变异与散发性脑出血（CH）风险之间的关联。我们在一项病例对照研究中对纤维蛋白原基因中的三个单核苷酸多态性（SNP）进行了基因分型分析，该研究纳入了 195 名 CH 患者和 116 名对照参与者；两组均为南方汉族人群。 logistic 回归分析表明，单体型 ATA（rs1800790+rs1800787+rs6050）、AA（rs1800790+rs6050）和 TA（rs1800787+rs6050）可使散发性 CH 的风险几乎增加一倍（比值比[OR]=1.738，95%置信区间[CI]：1.103-2.740，p=0.017；调整后的 OR=1.762，95% CI：1.042-2.982，p=0.035），尽管单独分析时这三个 SNP 与散发性 CH 无关。这些发现表明，rs1800790、rs1800787 和 rs6050 多态性可能导致中国人群散发性 CH 的病因。
