Department of Pediatrics, Jessenius Faculty of Medicine and University Hospital, Comenius University in Bratislava, Kollárova 2, 036 01, Martin, Slovakia.
Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia.
Mol Biol Rep. 2021 May;48(5):4397-4404. doi: 10.1007/s11033-021-06455-1. Epub 2021 Jun 1.
In complex etiopathogenesis of diabetic peripheral neuropathy (DPN), hemostatic dysfunction and subclinical inflammation play a possible role. Fibrinogen is involved in both the hemostatic and inflammatory pathways, so we hypothesize that fibrinogen gene polymorphisms might be associated with DPN. A total of 127 young patients with type 1 diabetes (T1D) (average age, 18.5 ± 4.65 years; average diabetes duration, 14.5 ± 2.26 years) and 90 healthy controls were enrolled into the study. Basic biochemical and coagulation parameters were measured and gene polymorphisms of fibrinogen alpha (rs6050) and beta (rs1800790) were established. DPN was diagnosed in 38 diabetic patients by neurological examination. AA genotype and A allele of rs1800790 polymorphism of fibrinogen beta were associated with increased risk of DPN (odds ratio [OR] 4.537, 95% confidence interval [95CI] 1.14-19.94, p = 0.019 and OR 1.958, 95CI 1.038-3.675, p = 0.029, respectively). No association was found between DPN and rs6050 gene polymorphisms. Plasma fibrinogen concentration significantly correlated with HbA1c (Spearman's correlation coefficient [r] = 0.54) and HDL cholesterol (r = - 0.67). A allele and AA genotype of rs1800790 seem to be associated with DPN in young patients with T1D. Further studies are appropriate to elucidate the role of fibrinogen gene polymorphisms in the complex etiology of DPN.
在糖尿病周围神经病变（DPN）的复杂发病机制中，止血功能障碍和亚临床炎症可能发挥作用。纤维蛋白原参与止血和炎症途径，因此我们假设纤维蛋白原基因多态性可能与 DPN 相关。共纳入 127 例年轻的 1 型糖尿病（T1D）患者（平均年龄 18.5±4.65 岁；平均糖尿病病程 14.5±2.26 年）和 90 例健康对照者。测定基本生化和凝血参数，并建立纤维蛋白原α（rs6050）和β（rs1800790）基因多态性。通过神经学检查诊断 38 例糖尿病患者患有 DPN。纤维蛋白原β rs1800790 的 AA 基因型和 A 等位基因与 DPN 的风险增加相关（优势比[OR] 4.537，95%置信区间[95CI] 1.14-19.94，p=0.019 和 OR 1.958，95CI 1.038-3.675，p=0.029）。未发现 DPN 与 rs6050 基因多态性之间存在关联。血浆纤维蛋白原浓度与 HbA1c（Spearman 相关系数[r] = 0.54）和 HDL 胆固醇（r = -0.67）显著相关。rs1800790 的 A 等位基因和 AA 基因型似乎与年轻 T1D 患者的 DPN 相关。需要进一步的研究来阐明纤维蛋白原基因多态性在 DPN 复杂病因学中的作用。
