School of Sport and Exercise Sciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, UK.
Brain Behav Immun. 2012 May;26(4):680-7. doi: 10.1016/j.bbi.2012.02.004. Epub 2012 Feb 22.
High intensity acute exercise at the time of vaccination has been shown to enhance the subsequent antibody response. This study examines whether an acute moderate intensity aerobic intervention prior to vaccination can enhance antibody response to pneumonia and half dose influenza vaccination. Sixty young (age (SD)=22.0 (6.1) years) and 60 older (age (SD)=57.5 (6.5) years) adults attended the laboratory on two separate occasions. At the first session, baseline antibody titres were determined, before participants completed either a brisk walk around campus at >55% of their age-predicted heart rate maximum, or a resting control condition, for 45 min. After the intervention, all participants received a full-dose pneumococcal vaccination and a half-dose influenza vaccination. Four weeks later, participants returned for a follow up blood sample. Multivariate ANOVA revealed an increase in total antibody titres against the influenza vaccine (F((12,106))=25.76, p<.001, η(2)=.75) and both the IgM (F((12,106))=17.10, p<.001, η(2)=.66) and IgG (F((12,106))=25.76, p<.001, η(2)=.75) antibody titres against the pneumococcal vaccine. However, there were no significant Time×Group interactions (p's all >.15), indicating that a 45 min brisk walk prior to vaccination did not affect antibody response to either the influenza or pneumonia vaccine. The results suggest that higher intensity exercise is necessary to augment antibody response to vaccination.
高强度的急性运动在接种疫苗时已被证明可以增强随后的抗体反应。本研究探讨了在接种疫苗前进行急性适度强度的有氧运动干预是否可以增强对肺炎和半剂量流感疫苗的抗体反应。60 名年轻（年龄（SD）=22.0（6.1）岁）和 60 名老年（年龄（SD）=57.5（6.5）岁）成年人分两次到实验室就诊。在第一次就诊时，确定了基线抗体滴度，然后参与者要么在校园内以超过其年龄预测最大心率的 55%以上的速度轻快地散步 45 分钟，要么进行休息对照条件。干预后，所有参与者都接受了一剂全剂量肺炎球菌疫苗和半剂量流感疫苗接种。四周后，参与者返回进行随访血样检查。多变量方差分析显示，流感疫苗的总抗体滴度增加（F((12,106))=25.76，p<.001，η(2)=.75）以及针对肺炎球菌疫苗的 IgM（F((12,106))=17.10，p<.001，η(2)=.66）和 IgG（F((12,106))=25.76，p<.001，η(2)=.75）抗体滴度都有所增加。然而，时间×组之间没有显著的相互作用（p 值均>.15），表明接种疫苗前进行 45 分钟的轻快步行不会影响流感或肺炎疫苗的抗体反应。结果表明，需要更高强度的运动才能增强对疫苗的抗体反应。
