Bohn-Goldbaum Erika, Pascoe April, Singh Maria Fiatarone, Singh Nalin, Kok Jen, Dwyer Dominic E, Mathieson Elizabeth, Booy Robert, Edwards Kate M
The University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, Australia.
The University of Sydney, Faculty of Health Sciences, Physical Activity, Lifestyle, Ageing and Wellbeing Research Group, Lidcombe, Australia.
Brain Behav Immun Health. 2019 Nov 14;1:100009. doi: 10.1016/j.bbih.2019.100009. eCollection 2020 Jan.
Although valuable and effective in decreasing disease burden, influenza vaccination has low rates of efficacy, especially in those at most risk. Studies have shown that acute exercise can improve vaccine responses, most consistently with weaker antigens. Here we examined the effect of resistance exercise on the acute and longer-term responses to influenza vaccination among healthy older adults. Forty-six participants (47.8% male, mean 73.4 ± 6.6 years) were randomised to perform one 45-min moderate-intensity resistance exercise session or sit quietly prior to the receipt of influenza vaccination. Acute exercise reduced vaccine reactions but had no effect on either antibody responses or development of influenza-like symptoms during six months of follow-up. Psychosocial and behavioural characteristics were examined for potential associations with the responses to vaccination. Participants (n = 36) vaccinated in the previous year had higher baseline antibody titres but not follow-up titres nor more frequent experience of influenza-like symptoms over 6 months compared to those unvaccinated in the previous year. These findings provide further support for the ability of acute exercise to reduce vaccine reactions and suggest risk factors for vaccine responses for future exploration.
尽管流感疫苗接种在减轻疾病负担方面有价值且有效，但疫苗效力较低，尤其是在风险最高的人群中。研究表明，急性运动可以改善疫苗反应，对较弱抗原的效果最为一致。在此，我们研究了抗阻运动对健康老年人流感疫苗接种急性和长期反应的影响。46名参与者（47.8%为男性，平均年龄73.4±6.6岁）被随机分配，在接种流感疫苗前进行一次45分钟的中等强度抗阻运动或安静坐着。急性运动减少了疫苗反应，但在六个月的随访期间，对抗体反应或流感样症状的出现均无影响。研究了心理社会和行为特征与疫苗接种反应之间的潜在关联。与前一年未接种疫苗的参与者相比，前一年接种过疫苗的参与者（n = 36）基线抗体滴度较高，但随访滴度以及六个月内流感样症状的发作频率并无差异。这些发现为急性运动减轻疫苗反应的能力提供了进一步支持，并提示了未来可供探索的疫苗反应风险因素。
