College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
Infect Genet Evol. 2012 Jul;12(5):933-46. doi: 10.1016/j.meegid.2012.02.001. Epub 2012 Feb 20.
We compared the genetic and biologic characteristics of 35 influenza viruses of different epidemiological backgrounds in Korea, including H3N2 canine influenza virus (CIV). Phylogenetic analysis revealed that chicken adapted H9N2 viruses (A/chicken/Korea/96006/96 [CK/Kor/96006-like]) have acquired aquatic avian gene segments through reassortment, and these reassorted H9N2 viruses were more frequently detected from minor poultry species than from industrial poultry. Conversely, gene segments from CK/Kor/96006-like viruses were also detected in most of the viruses from domestic ducks. Interestingly, domestic ducks, rather than wild aquatic birds, harbored close relatives of all eight gene segments of H3N2 CIV, which preferred binding to avian receptors. Therefore, bidirectional virus transmission events are assumed to have occurred between land-based poultry and aquatic poultry, in particular within the non-industrial poultry system. These events have contributed to the generation of a novel reassortant, H3N2 CIV. To prevent generating other reassortants capable of interspecies transmission, gene movements in the non-industrial poultry systems should be clarified and managed.
我们比较了韩国 35 种不同流行病学背景的流感病毒的遗传和生物学特征,包括 H3N2 犬流感病毒(CIV)。系统进化分析显示,鸡源适应的 H9N2 病毒(A/鸡/韩国/96006/96[CK/Kor/96006-样])通过重配获得了水生禽的基因片段,这些重配的 H9N2 病毒在小型家禽中比在工业家禽中更频繁地被检测到。相反,CK/Kor/96006-样病毒的基因片段也在大多数来自家养鸭的病毒中被检测到。有趣的是,家养鸭而不是野生水禽,携带了 H3N2 CIV 的所有 8 个基因片段的近亲,这些近亲更喜欢结合禽受体。因此,假定在陆基家禽和水禽之间,特别是在非工业家禽系统中,发生了双向病毒传播事件。这些事件促成了一种新型重配的 H3N2 CIV 的产生。为了防止产生其他能够在种间传播的重组病毒,应该阐明和管理非工业家禽系统中的基因运动。