Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.
Cell Calcium. 2012 Jul;52(1):52-6. doi: 10.1016/j.ceca.2012.02.003. Epub 2012 Mar 3.
One widespread and conserved Ca(2+) entry pathway in eukaryotic cells is the store-operated CRAC channel and Ca(2+) entry through these channels activates a disparate array of cellular responses. Under physiological conditions, mitochondria are important regulators of CRAC channel gating. Through these actions, mitochondria help control a range of spatially and temporally distinct CRAC channel-driven responses including enzyme activation, secretion, intercellular communication through paracrine signals and gene expression.
真核细胞中一种广泛而保守的钙离子内流途径是钙库操纵的 CRAC 通道，通过这些通道的钙离子内流激活了一系列不同的细胞反应。在生理条件下，线粒体是 CRAC 通道门控的重要调节因子。通过这些作用，线粒体有助于控制一系列空间和时间上不同的由 CRAC 通道驱动的反应，包括酶的激活、分泌、通过旁分泌信号的细胞间通讯和基因表达。
