Indiana University School of Medicine, 550 North University Boulevard, Indianapolis, IN 46202, USA.
Clin Gastroenterol Hepatol. 2012 Aug;10(8):920-4. doi: 10.1016/j.cgh.2012.02.019. Epub 2012 Mar 2.
BACKGROUND & AIMS: Many advances have been made in pancreatobiliary imaging and endoscopy techniques. However, little is known about trends in use of endoscopic retrograde cholangiopancreatography (ERCP).
We performed a retrospective cohort study that analyzed data from 33,596 ERCPs performed at Indiana University Medical Center from 1994 to 2009. Data from all patients were entered into an endoscopy database. We compared changes in patient demographics, indications for ERCP, and utilization of specific ERCP therapies during this time period.
The annual volume of ECRP increased steadily from 1175 in 1994 to 2802 in 2009 (P < .0001). Of all patients, 33.9% had previously undergone an ERCP at a different facility; 42.3% of these were unsuccessful. The odds of having undergone a failed ERCP at another facility increased slightly each year (odds ratio, 1.02; P < .001). Among patients who had a failed ERCP elsewhere, the success rate at Indiana University Medical Center was 96.1%. The frequency of patients with American Society of Anesthesiologists class ≥3 (odds ratio, 1.12; P < .001) who received anesthesia-administered sedation increased each year (odds ratio, 1.25; P < .001). Most ERCPs were performed for common bile duct stones or strictures and suspected sphincter of Oddi dysfunction (77.2%). The most rapid increase was among procedures for common bile duct strictures or leaks, pancreatic duct stones or strictures, and suspected sphincter of Oddi dysfunction. Rates of biliary sphincterotomy did not change (P = .252), but the frequency of pancreatic sphincterotomy, common bile duct, or pancreatic duct stent placement and pancreatic duct stricture dilation increased during this time (P < .001 for each).
At a referral center, ERCP has become increasingly complex. From 1994 to 2009, increasing numbers of ERCPs have been performed for patients with more comorbidities, higher-grade disease, history of failed ERCPs, and on those receiving endotherapy.
胆胰影像学和内镜技术取得了诸多进展。然而,对于内镜逆行胰胆管造影术(ERCP)应用趋势的了解甚少。
我们进行了一项回顾性队列研究,分析了印第安纳大学医学中心 1994 年至 2009 年间 33596 例 ERCP 数据。所有患者的数据均录入内镜数据库。在此期间,我们比较了患者人口统计学特征、ERCP 适应证以及特定 ERCP 治疗方法的应用变化。
ERCP 年例数从 1994 年的 1175 例稳步增加至 2009 年的 2802 例(P<0.0001)。所有患者中,33.9%曾在其他机构行过 ERCP,其中 42.3%的患者治疗失败。在其他机构行 ERCP 治疗失败的患者,每年发生的可能性略有增加(比值比,1.02;P<0.001)。在曾于其他机构治疗失败的患者中,在印第安纳大学医学中心的成功率为 96.1%。每年接受麻醉镇静的美国麻醉医师协会(ASA)分级≥3 的患者比例逐渐升高(比值比,1.12;P<0.001)(比值比,1.25;P<0.001)。大多数 ERCP 是为胆总管结石或狭窄和可疑Oddi 括约肌功能障碍(77.2%)而进行的。增加最迅速的是胆总管狭窄或漏、胰管结石或狭窄和可疑Oddi 括约肌功能障碍的操作。胆管括约肌切开术的比例没有变化(P=0.252),但胰管括约肌切开术、胆总管或胰管支架置入术以及胰管狭窄扩张术的频率在此期间增加(P<0.001)。
在转诊中心,ERCP 变得越来越复杂。从 1994 年到 2009 年,接受治疗的患者的 ERCP 数量不断增加,他们具有更多的合并症、更严重的疾病、ERCP 失败史以及需要内镜治疗。