Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Crnotravska 17, 11002 Belgrade, Serbia.
Immunol Res. 2012 Apr;52(1-2):133-8. doi: 10.1007/s12026-012-8280-z.
Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increased accumulation of granulocytes in the lungs or liver, the results from our laboratory demonstrated reduced granulocyte influx in the wound that heals in conditions of thermal injury. We also demonstrated evidence that indicates impaired signal transduction in granulocytes following thermal injury, as well as their divergent response regarding the adhesiveness, oxidative burst and nitric oxide production at the wound site.
热烧伤和其他形式的严重创伤会引起同时的过度炎症反应和抗炎反应。虽然关于 T 淋巴细胞数量减少和反应性降低的数据基本一致，但关于创伤后粒细胞的报告却相互矛盾。与肺部或肝脏中粒细胞积累增加的证据相反，我们实验室的结果表明，在热烧伤条件下愈合的伤口中，粒细胞的流入减少。我们还证明了热烧伤后粒细胞信号转导受损的证据，以及它们在创伤部位的黏附性、氧化爆发和一氧化氮产生方面的不同反应。
