通过使用具有 C-N 螯合酰胺配体的双功能铱配合物的化学酶催化体系对映选择性地动态动力学拆分外消旋仲醇。
Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with C-N chelate amido ligands.
机构信息
Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, O-okayama 2-12-1-E4-1, Tokyo 152-8552, Japan.
出版信息
Chem Commun (Camb). 2012 Apr 14;48(30):3635-7. doi: 10.1039/c2cc30333g. Epub 2012 Mar 2.
PMID:22389045
Abstract
The combined catalyst system of bifunctional amidoiridium complexes derived from benzylic amines with CALB was found to provide a range of chiral acetates from racemic secondary alcohols in excellent yields with nearly perfect enantioselectivities via dynamic kinetic resolution.
摘要
研究发现，手性苄胺衍生的双功能酰氨基铱配合物与 CALB 的组合催化剂体系通过动力学拆分可以从外消旋仲醇中以优异的收率和近乎完美的对映选择性得到一系列手性乙酸酯。
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