胶质母细胞瘤中的离子通道
Ion channels in glioblastoma.
作者信息
Molenaar Remco J
机构信息
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
出版信息
ISRN Neurol. 2011;2011:590249. doi: 10.5402/2011/590249. Epub 2011 Nov 29.
Abstract
Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated in glioblastoma proliferation, migration, and invasion. This paper summarizes studies on potassium, sodium, chloride, and calcium channels of glioblastoma. It provides an up-to-date overview of the literature that could ultimately lead to new therapeutic targets.
摘要
胶质母细胞瘤是最常见的原发性脑肿瘤，预后最差。其特征是广泛侵袭、迁移和血管生成。由于这种特性，中位生存期仅为15个月，导致局部手术切除无效且无法进行充分的放疗。目前，几种离子通道已被认为与胶质母细胞瘤的增殖、迁移和侵袭有关。本文总结了关于胶质母细胞瘤钾、钠、氯和钙通道的研究。它提供了一份最新的文献综述，最终可能会产生新的治疗靶点。
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