Clarke Jennifer, Butowski Nicholas, Chang Susan
Division of Neuro-Oncology, Department of Neurological Surgery, University of California, San Francisco, 400 Parnassus Ave, Room A-808, Box 0372, San Francisco, CA 94143-0372, USA.
Arch Neurol. 2010 Mar;67(3):279-83. doi: 10.1001/archneurol.2010.5.
Glioblastoma is the most common primary malignant brain tumor in adults and is a challenging disease to treat. The current standard of care includes maximal safe surgical resection, followed by a combination of radiation and chemotherapy with temozolomide. Despite that, recurrence is quite common, and so we continue to search for more effective treatments both for initial therapy and at the time of recurrence. This article will review recent advances in therapy for glioblastoma, including surgery, radiotherapy, cytotoxic chemotherapies, molecularly targeted agents, and immunotherapy; the role of antiangiogenic agents in the treatment of glioblastoma is discussed in a separate article in this issue of the Archives.
胶质母细胞瘤是成人中最常见的原发性恶性脑肿瘤，也是一种治疗具有挑战性的疾病。当前的标准治疗方案包括最大程度的安全手术切除，随后联合放疗和替莫唑胺化疗。尽管如此，复发仍很常见，因此我们继续寻找更有效的初始治疗和复发时的治疗方法。本文将综述胶质母细胞瘤治疗的最新进展，包括手术、放疗、细胞毒性化疗、分子靶向药物和免疫疗法；抗血管生成药物在胶质母细胞瘤治疗中的作用在本期《Archives》的另一篇文章中讨论。
