Bolotovskiĭ V M, Gelikman B G, Mikheeva I V, Shubin N S, Glinskaia E V
Zh Mikrobiol Epidemiol Immunobiol. 1990 Aug(8):42-6.
The immunoepidemiological survey of 54 foci of epidemic parotitis showed that the epidemiological effectiveness index at preschool institutions, equal to 2.7, was essentially higher than at schools (2.1). The significant difference (t = 3.35) in the epidemiological effectiveness indices was due to the presence of a large number of persons having had inapparent and faintly pronounced forms of epidemic parotitis among school children, as well as due to more close contacts of children with the foci of infection at preschool institutions. The study showed that among children immunized with some lots of parotitis vaccine elevated morbidity in epidemic parotitis was registered. In the foci of infection children, immunized in the presence of low initial titers of specific hemagglutinins in their sera, responded by a booster effect with different duration of stimulation of antibody formation. The hemagglutinin titer of 1:20 was shown to protect children from epidemic parotitis.
对54个流行性腮腺炎疫点的免疫流行病学调查表明,学前机构的流行病学效果指数为2.7,明显高于学校(2.1)。流行病学效果指数的显著差异(t = 3.35)是由于学龄儿童中存在大量患有无症状和症状轻微的流行性腮腺炎的人,以及由于学前机构中儿童与感染源的接触更为密切。研究表明,在接种了某些批次腮腺炎疫苗的儿童中,记录到流行性腮腺炎发病率升高。在感染源的儿童中,血清中特异性血凝素初始滴度较低时进行免疫接种,会产生不同持续时间的抗体形成刺激的增强效应。血凝素滴度为1:20可保护儿童预防流行性腮腺炎。