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[野生流行性腮腺炎病毒在腮腺炎感染病灶处的免疫和免疫调节活性]

[Immunizing and immunomodulating activity of a wild epidemic parotitis virus at a parotitis infection focus].

作者信息

Iuminova N V, Krasnova V P, Glazkova N V

出版信息

Vopr Virusol. 1995 May-Jun;40(3):124-6.

PMID:7676675
Abstract

The immune status of 18 children previously vaccinated or not with live parotitis vaccine and living in a focus of parotitis was tested over time. Specific antibodies were found in the blood sera or nasal secretion of 88.9% children by follow-up days 10-20, and memory antigen-reactive cells were forming in 55.6%. Functional temporary T-immunodeficiency was observed at the same period in 66.7% children. Although there were no cases of clinically apparent epidemic parotitis, immunologic studies confirmed the circulation of wild type virus. Immunologic studies detected 2 cases of inapparent course of epidemic parotitis.

摘要

对18名曾接种或未接种过流行性腮腺炎活疫苗且生活在腮腺炎疫区的儿童的免疫状况进行了长期检测。在随访的第10 - 20天,88.9%的儿童血清或鼻分泌物中发现了特异性抗体,55.6%的儿童体内正在形成记忆抗原反应细胞。同期,66.7%的儿童出现功能性暂时性T细胞免疫缺陷。虽然没有临床明显的流行性腮腺炎病例,但免疫学研究证实了野生型病毒的传播。免疫学研究检测到2例流行性腮腺炎隐性感染病例。

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