Bonakdaran S H, Khajeh-Dalouie M
Endocrine Research Center, Mashhad University of Medical Sciences, Iran.
Med J Malaysia. 2011 Dec;66(5):447-50.
Safety of fasting in Ramadan for diabetic patients is not clearly known. The aim of this study was to determine the effects of fasting on glycemic excursions by continuous glucose monitoring system (CGMS).
This pilot, observational study conducted in the Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad, IRAN, in Ramadan 2008. Seventeen well controlled patients with diabetes type 2 who were taking oral agents underwent 72 hour monitoring of glycemic excursions by CGMS one month before Ramadan and during Ramadan. The extent and duration of hyperglycemic and hypoglycemic events were evaluated and compared.
A significant reduction in hyperglycemic events was observed during Ramadan. The extent and duration of hypoglycemic events was not significantly different between two states (Ramadan and before). A significant increase in number of hypoglycemic events in Ramadan was found in patients who take sulfonylurea compared with those who take only metformin.
Fasting in Ramadan can be safe for well controlled patients with type 2 diabetes.
斋月期间糖尿病患者禁食的安全性尚不清楚。本研究的目的是通过连续血糖监测系统（CGMS）确定禁食对血糖波动的影响。
本前瞻性观察性研究于2008年斋月期间在伊朗马什哈德医科大学内分泌研究中心进行。17名服用口服降糖药且病情控制良好的2型糖尿病患者在斋月前一个月和斋月期间通过CGMS进行了72小时的血糖波动监测。评估并比较了高血糖和低血糖事件的程度及持续时间。
斋月期间高血糖事件显著减少。两种状态（斋月期间和斋月前）低血糖事件的程度和持续时间无显著差异。与仅服用二甲双胍的患者相比，服用磺脲类药物的患者在斋月期间低血糖事件数量显著增加。
斋月期间禁食对病情控制良好的2型糖尿病患者可能是安全的。
