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芬兰脊髓灰质炎疫苗接种的效果。

The efficacy of polio vaccination in Finland.

作者信息

Lapinleimu K, Stenvik M

出版信息

Dev Biol Stand. 1978;41:137-9.

PMID:223906
Abstract

The inactivated polio vaccine has eliminated not only the disease but also polioviruses from Finland. The last endemic cases of poliomyelitis were seen in 1961, and two were imported in 1964. To check whether polioviruses were still circulating in Finland, an intensified search for polioviruses was carried out in 1972-1974 in sewage, among patients with polio-like diseases and among healthy preschool children. Viruses, mostly Coxsackie B viruses, were isolated from sewage in 67% of the samples, but no polioviruses. The etiology of aseptic meningitis and other polio-like diseases was explained in 52% of the cases, but without isolation of any polioviruses. Faeces samples from 4878 different preschool children were examined: 15.7% of them excreted viruses, but not polioviruses.

摘要

灭活脊髓灰质炎疫苗不仅在芬兰消灭了该疾病,还消除了脊髓灰质炎病毒。芬兰最后一例本土脊髓灰质炎病例出现在1961年,1964年有两例输入病例。为了检查脊髓灰质炎病毒是否仍在芬兰传播,1972年至1974年在污水中、患有脊髓灰质炎样疾病的患者以及健康学龄前儿童中开展了强化的脊髓灰质炎病毒搜寻工作。在67%的污水样本中分离出了病毒,主要是柯萨奇B病毒,但未分离出脊髓灰质炎病毒。52%的无菌性脑膜炎和其他脊髓灰质炎样疾病病例的病因得到了解释,但未分离出任何脊髓灰质炎病毒。对4878名不同学龄前儿童的粪便样本进行了检测:其中15.7%的儿童排出了病毒,但不是脊髓灰质炎病毒。

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