Wennink J M, Delemarre-van de Waal H A, Schoemaker R, Blaauw G, van den Braken C, Schoemaker J
Department of Pediatrics, Academic Hospital of the Vrije Universiteit, Amsterdam, The Netherlands.
Acta Endocrinol (Copenh). 1990 Sep;123(3):263-70. doi: 10.1530/acta.0.1230263.
Pulsatile growth hormone secretion patterns were studied in relation to LH and testosterone release in 30 healthy prepubertal boys and 2 adult men. Plasma GH was measured every 10 min, plasma LH and testosterone every hour. Night-time GH secretion parameters were 2-3 times higher than daytime values. During daytime, mean GH level and the fraction of GH in pulses increased from Tanner stage G2 to G4 (p = 0.01); during night-time these parameters increased as well (p less than or equal to 0.1) and decreased from stage G5 to adulthood (p = 0.05). GH pulse number did not increase; the number of high-amplitude (greater than 8 micrograms/l pulses, however, increased from stage G2 to G4 (p = 0.05) during the day. Height velocity correlated with their number of high pulses during day and night (tau = 0.39, p less than 0.003). From stage G2 to G4 significant correlations were observed between nocturnal testosterone levels and GH secretion parameters (tau = 0.53-0.57), in contrast to nocturnal LH levels. It is concluded that during puberty 1. GH secretion increases as a result of an increased pulse amplitude; 2. there is no consistent correlation between GH and LH levels; 3. increasing nocturnal testosterone levels are correlated with the increasing GH secretion; therefore GnRH does not seem to influence GH secretion directly, but an indirect effect via testosterone is more conceivable, and 4. height velocity is correlated with the number of high GH pulses.
在30名健康的青春期前男孩和2名成年男性中，研究了脉冲式生长激素分泌模式与促黄体生成素（LH）和睾酮释放的关系。每10分钟测量一次血浆生长激素（GH），每小时测量一次血浆LH和睾酮。夜间GH分泌参数比白天值高2 - 3倍。在白天，平均GH水平和脉冲中GH的比例从坦纳（Tanner）分期G2到G4升高（p = 0.01）；在夜间，这些参数也升高（p≤0.1），并从G5期到成年期下降（p = 0.05）。GH脉冲次数没有增加；然而，白天高振幅（大于8微克/升）脉冲的数量从G2期到G4期增加（p = 0.05）。身高增长速度与白天和夜间高脉冲的数量相关（tau = 0.39，p＜0.003）。从G2期到G4期，观察到夜间睾酮水平与GH分泌参数之间存在显著相关性（tau = 0.53 - 0.57），与夜间LH水平相反。结论是，在青春期：1. 由于脉冲振幅增加，GH分泌增加；2. GH和LH水平之间没有一致的相关性；3. 夜间睾酮水平升高与GH分泌增加相关；因此，促性腺激素释放激素（GnRH）似乎不直接影响GH分泌，但通过睾酮的间接作用更值得考虑；4. 身高增长速度与高GH脉冲的数量相关。
