Wennink J M, Delemarre-van de Waal H A, Schoemaker R, Blaauw G, van den Braken C, Schoemaker J
Department of Pediatrics, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands.
Acta Endocrinol (Copenh). 1991 Feb;124(2):129-35. doi: 10.1530/acta.0.1240129.
Pulsatile growth hormone secretion patterns were studied in relation to luteinizing hormone and estradiol release in 33 healthy (pre)pubertal girls. Plasma GH was determined every 10 min, plasma LH and E2 every hour. Night-time GH release was always higher than daytime GH release. During daytime, all GH secretion parameters, except for the basal GH level, increased significantly from the prepubertal stage to stage B4 before (m-) the menarche (p = 0.05) and decreased thereafter (p = 0.05). During night-time, mean GH level and the fraction of GH in pulses also tended to increase from stage B1 to stage B4m-. The number of high pulses (greater than 8 micrograms/l) during day and night together tended to increase until stage B4m- and decreased after the menarche (p = 0.05). Height velocity did not correlate with the number of high pulses (Kendall tau = 0.14, p = 0.14). From stage B1 to B4m- high correlations were observed between E2 levels and GH secretion parameters, particularly during the day (tau = 0.59-0.71, p less than or equal to 0.01). The correlations between LH levels and GH secretion were high as well (tau = 0.50-0.81, p less than or equal to 0.01), but equal during day and night. It is concluded that during puberty 1. spontaneous GH release in girls increases 2-3 fold until the menarche and decreases thereafter, primarily as the result of an increasing and decreasing GH pulse amplitude; 2. diurnally increasing estradiol levels correlated with increasing GH secretion.
在33名健康的青春期前女孩中，研究了脉冲式生长激素分泌模式与促黄体生成素和雌二醇释放的关系。每10分钟测定一次血浆生长激素（GH），每小时测定一次血浆促黄体生成素（LH）和雌二醇（E2）。夜间GH释放总是高于白天GH释放。在白天，除基础GH水平外，所有GH分泌参数从青春期前阶段到初潮前（m-）的B4期均显著增加（p = 0.05），此后下降（p = 0.05）。在夜间，平均GH水平和脉冲中GH的比例也倾向于从B1期到B4m-期增加。白天和夜间总的高脉冲数（大于8微克/升）倾向于增加直到B4m-期，并在初潮后下降（p = 0.05）。身高增长速度与高脉冲数无关（肯德尔tau系数 = 0.14，p = 0.14）。从B1期到B4m-期，观察到E2水平与GH分泌参数之间存在高度相关性，特别是在白天（tau系数 = 0.59 - 0.71，p≤0.01）。LH水平与GH分泌之间的相关性也很高（tau系数 = 0.50 - 0.81，p≤0.01），但在白天和夜间相同。研究得出结论，在青春期：1. 女孩的自发性GH释放在初潮前增加2 - 3倍，此后下降，主要是由于GH脉冲幅度的增加和减少；2. 日间升高的雌二醇水平与增加的GH分泌相关。
