MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China.
Org Lett. 2012 Mar 16;14(6):1472-5. doi: 10.1021/ol300205r. Epub 2012 Mar 5.
Both copper(II)-mediated oxidative C-H bond activation and oxidative addition of copper(I) into a C-I bond produced an identical and structurally well-defined aryl-Cu(III) intermediate. The cross-coupling reaction of an aryl-Cu(III) intermediate with both terminal alkynes at an elevated temperature and alkynyllithium reagents under mild conditions led effectively to the formation of a C(aryl)-C(alkynyl) bond. An alternative mechanism has been proposed for the Castro-Stephens reaction.
铜（II）介导的氧化 C-H 键活化和氧化加成铜（I）进入 C-I 键产生了相同的、结构定义良好的芳基-Cu(III)中间体。芳基-Cu(III)中间体与末端炔烃在高温下以及在温和条件下与炔基锂试剂的交叉偶联反应有效地导致了 C（芳基）-C（炔基）键的形成。已经为 Castro-Stephens 反应提出了一种替代机制。
