通过结构明确的芳基-Cu(III)中间体，由 Cu(ClO4)2 介导的芳基与烷基锂试剂之间的氧化交叉偶联反应，实现 C(aryl)-C(alkyl) 键的形成。
C(aryl)-C(alkyl) bond formation from Cu(ClO4)2-mediated oxidative cross coupling reaction between arenes and alkyllithium reagents through structurally well-defined Ar-Cu(III) intermediates.
机构信息
Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
出版信息
Chem Commun (Camb). 2012 Sep 28;48(75):9418-20. doi: 10.1039/c2cc35067j. Epub 2012 Aug 14.
PMID:22892907
Abstract
The stable and structurally well-defined Ar-Cu(III) intermediates, that are prepared almost quantitatively from the reaction of azacalix[1]arene[3]pyridines with Cu(ClO(4))(2)·6H(2)O under aerobic conditions, reacted smoothly with a number of alkyllithium reagents under mild conditions to form C(aryl)-C(alkyl) bonds.
摘要
在有氧条件下，几乎定量地从氮杂杯[1]芳烃[3]吡啶与 Cu(ClO4)2·6H2O 的反应中制备得到稳定且结构明确的 Ar-Cu(III)中间体，该中间体在温和条件下与多种烷基锂试剂顺利反应，形成 C(芳基)-C(烷基)键。
Zotero 插件