Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India.
Neurosci Biobehav Rev. 2012 May;36(5):1376-81. doi: 10.1016/j.neubiorev.2012.02.013. Epub 2012 Feb 27.
Traumatic brain injury (TBI) constitutes a major global health and socio-economic problem with neurobehavioral sequelae contributing to long-term disability. It causes brain swelling, axonal injury and hypoxia, disrupts blood brain barrier function and increases inflammatory responses, oxidative stress, neurodegeneration and leads to cognitive impairment. Epidemiological studies show that 30% of patients, who die of TBI, have Aβ plaques which are pathological features of Alzheimer's disease (AD). Thus TBI acts as an important epigenetic risk factor for AD. This review focuses on AD related genes which are expressed during TBI and its relevance to progression of the disease. Such understanding will help to diagnose the risk of TBI patients to develop AD and design therapeutic interventions.
创伤性脑损伤（TBI）是一个全球性的重大健康和社会经济问题，其神经行为后遗症导致长期残疾。TBI 导致脑肿胀、轴突损伤和缺氧，破坏血脑屏障功能，增加炎症反应、氧化应激、神经退行性变，导致认知障碍。流行病学研究表明，30%死于 TBI 的患者有 Aβ斑块，这是阿尔茨海默病（AD）的病理特征。因此，TBI 是 AD 的一个重要表观遗传危险因素。本综述重点介绍了 TBI 期间表达的与 AD 相关的基因及其与疾病进展的相关性。这种理解将有助于诊断 TBI 患者发生 AD 的风险，并设计治疗干预措施。
