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[髋关节置换手术中血栓栓塞的风险及其通过个体化肝素剂量给药的预防]

[The risk of thromboembolism in prosthetic surgery of the hip, and its prevention by administration of individualized heparin dosages].

作者信息

Hernandez-Vaquero D

机构信息

Service de Traumatologie et Orthopédie, Hôpital de l'Insalud d'Avilés, Départment de Chirurgie, Université d'Oviedo, Espagne.

出版信息

Acta Orthop Belg. 1990;56(2):445-50.

PMID:2239191
Abstract

After hip replacement, thromboemboli remain a very frequent and severe complication. Different techniques of prevention have been described but there is no pharmacological method of definitively proving the effectiveness of such techniques. The use of low-dose heparin has been recommended, but owing to the variable results obtained in this type of surgery, certain authors prefer using an individualized dose. The authors report their experience with this regimen in 30 patients with certain individual thromboembolic risk factors who underwent hip arthroplasty. Despite these cases of deep vein thrombosis, no symptomatic pulmonary emboli were diagnosed. There were two patients with hematomas at the iliac crest which resolved without sequelae after drainage. The different rules to be followed for prevention of these complications are analyzed; the authors underscore the need for individual adaptation of the heparin dose.

摘要

髋关节置换术后,血栓栓塞仍然是一种非常常见且严重的并发症。已有多种预防技术被描述,但尚无药理学方法能确切证明这些技术的有效性。低剂量肝素的使用已被推荐,但鉴于这类手术中获得的结果存在差异,某些作者更倾向于使用个体化剂量。作者报告了他们对30例具有特定个体血栓栓塞危险因素且接受髋关节置换术患者采用该方案的经验。尽管有这些深静脉血栓形成的病例,但未诊断出有症状的肺栓塞。有两名患者在髂嵴处出现血肿,引流后未留后遗症而消退。分析了预防这些并发症需遵循的不同规则;作者强调了肝素剂量个体化调整的必要性。

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