Le Guyader H M, Perramant Y, Tepaut D, De Tinteniac A, Egreteau J P
Service d'orthopédie, Centre hospitalier régional et universitaire de Brest.
Agressologie. 1990 Mar;31(3):155-7.
Orthopedic départment of Centre hospitalo-universitaire de Brest use one upon another two procedures: from 1974 to 1984, for 1287 cases the prevention of thromboembolic complications is done with the help of subcutaneous heparin at standard dose during 12 days; the clinical diagnosis in confirmed by an isotopic phlebography and isotopic lung scan. In 1986 and 1987, for 391 cases this prevention is done with the help of subcutaneous heparin in adapted doses during 21 days; the clinical diagnosis is confirmed by X ray phlebography and isotopic lung scan. The frequency of thromboembolic complications has been 4.6% in the first period and 1.2% in the second period. This results confirm the role of heparin in preventing post operative thromboembolic complications after total hip replacement. The results after knee arthroplasty are not so good.
1974年至1984年，针对1287例患者，在12天内使用标准剂量的皮下肝素预防血栓栓塞并发症；临床诊断通过同位素静脉造影和同位素肺部扫描得以证实。1986年和1987年，针对391例患者，在21天内使用调整剂量的皮下肝素进行预防；临床诊断通过X线静脉造影和同位素肺部扫描得以证实。血栓栓塞并发症的发生率在第一阶段为4.6%，在第二阶段为1.2%。这些结果证实了肝素在全髋关节置换术后预防血栓栓塞并发症中的作用。膝关节置换术后的结果则没那么理想。
