Frauenknecht V, Schroeder V
Universitätsklinik für Hämatologie, Hämostase Forschungslabor, Universitätsspital und Universität Bern, Schweiz.
Hamostaseologie. 2012;32(4):276-85. doi: 10.5482/ha-1191. Epub 2012 Mar 6.
Atherosclerotic diseases such as coronary artery disease and ischaemic stroke are caused by chronic inflammation in arterial vessel walls. The complement system is part of the innate immune system. It is involved in many processes contributing to onset and development of atherosclerotic plaques up to the final stage of acute thrombotic events. This is due to its prominent role in inflammatory processes. In addition, there is increasing evidence that interactions between complement and coagulation provide a link between inflammation and thrombosis. On the other hand, the complement system also has an atheroprotective function through the clearance of apoptotic material. The knowledge of these complex mechanisms will become increasingly important, also for clinicians, since it may lead to novel therapeutic and diagnostic options. Therapies targeting the complement system have the potential to reduce tissue damage caused by acute ischaemic events. Whether early anti-inflammatory and anti-complement therapy may be able to prevent atherosclerosis, remains a hot topic for research.
诸如冠状动脉疾病和缺血性中风等动脉粥样硬化疾病是由动脉血管壁的慢性炎症引起的。补体系统是固有免疫系统的一部分。它参与了许多促成动脉粥样硬化斑块发生和发展直至急性血栓形成事件最后阶段的过程。这是由于其在炎症过程中发挥的重要作用。此外，越来越多的证据表明补体与凝血之间的相互作用在炎症和血栓形成之间建立了联系。另一方面，补体系统还通过清除凋亡物质发挥抗动脉粥样硬化作用。了解这些复杂机制对临床医生也将变得越来越重要，因为这可能会带来新的治疗和诊断选择。针对补体系统的疗法有可能减少急性缺血事件造成的组织损伤。早期抗炎和抗补体疗法是否能够预防动脉粥样硬化，仍然是一个热门研究课题。
