Department of Community Medicine, Faculty of Medicine, Hashemite University, Zarqa, Jordan.
Matern Child Health J. 2013 Feb;17(2):368-73. doi: 10.1007/s10995-012-0981-3.
The efficacy of daily versus twice weekly and once weekly oral iron therapy was analyzed to optimize a protocol for treatment of IDM among Jordanian children. One hundred and forty-eight children aged between 6 and 60 months with Hb estimate less than 11 gm/dl were screened. They were randomly divided into three regimens of oral iron therapy for a period of 12 weeks; a group was supplemented with a single weekly dose of iron; a second group received two doses weekly; and a third group had a daily dose of iron. Hb was assayed 3 and 12 weeks after therapy, while ferritin was assayed after 12 weeks of treatment. A significant rise in Hb concentration was observed which was most significant 12 weeks after treatment. Iron supplementation after 3 weeks was similar in all treated groups, and no significant difference in Hb concentration among the three groups was noticed. By the end of the third week, the anemia had respectively resolved by 18, 11.8 and 23.4% in the daily, twice weekly, and once weekly groups. On the other hand, the percentage of recovery of anemia respectively was 78, 90.2 and 74.5% at the end of 12 weeks of iron therapy. Hb recovery percentage was comparable in the three treated groups, and no significant difference was reported between them either at 3 or at 12 weeks of therapy. Ferritin levels in the daily and twice weekly treated groups were similar after 12 weeks of iron therapy and were significantly higher than the ferritin levels of weekly treated group. Although the anemia in the three treated groups was resolved after 3 and 12 weeks of oral iron therapy, we conclude that the regimen of two doses per week is the most effective in resolving anemia with less cost and fewer side effects.
本研究旨在分析每日、每周 2 次和每周 1 次口服铁剂治疗方案的疗效，以优化约旦儿童缺铁性贫血（IDA）的治疗方案。共纳入 148 名 6-60 月龄、Hb 估计值＜11 g/dl 的患儿，将其随机分为 3 组，分别接受为期 12 周的口服铁剂治疗：每周单次剂量补铁组、每周 2 次剂量补铁组和每日剂量补铁组。治疗 3 周和 12 周后检测 Hb，治疗 12 周后检测铁蛋白。结果显示，Hb 浓度显著升高，治疗 12 周时最为显著。治疗 3 周时，各组铁剂补充量相似，3 组间 Hb 浓度无显著差异。治疗第 3 周末，每日、每周 2 次和每周 1 次补铁组的贫血缓解率分别为 18%、11.8%和 23.4%。而在治疗 12 周时，3 组的贫血缓解率分别为 78%、90.2%和 74.5%。3 组治疗后 Hb 恢复率相似，治疗 3 周和 12 周时组间均无显著差异。治疗 12 周后，每日和每周 2 次补铁组的铁蛋白水平相似，且显著高于每周 1 次补铁组。虽然 3 组患儿在接受口服铁剂治疗 3 周和 12 周后贫血均得到缓解，但我们认为每周 2 次补铁方案疗效最佳，且费用较低、不良反应较少。
