Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
J Magn Reson Imaging. 2012 Jul;36(1):145-51. doi: 10.1002/jmri.23635. Epub 2012 Mar 5.
To investigate whether a correlation exists between perfusion parameters obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and prognostic factors or immunohistochemical subtypes of breast cancers.
Quantitative parameters (K(trans) , k(ep) , and v(e) ) of 70 invasive ductal carcinomas were obtained using DCE-MRI as a postprocessing procedure. Correlations between parameters and prognostic factors, including tumor size, axillary nodal status, histologic grade, nuclear grade, expression of estrogen receptor (ER), progesterone receptor (PR), Ki-67, p53, bcl-2, and human epidermal growth factor receptor 2 (HER2) and subtypes categorized as luminal (ER or PR-positive), triple negative (ER or PR-negative, HER2-negative), and HER2 (ER and PR-negative, HER2 overexpression) were analyzed.
Mean K(trans) was higher in tumors with a high histologic grade than with a low histologic grade (P = 0.007), with a high nuclear grade than with a low nuclear grade (P = 0.002), and with ER negativity than ER positivity (P = 0.056). Mean k(ep) was higher in tumors with a high histologic grade than with a low histologic grade (P = 0.005), with a high nuclear grade than with a low nuclear grade (P = 0.001), and with ER negativity than with ER positivity (P = 0.043). Mean v(e) was lower in tumors with a high histologic grade than with a low histologic grade (P = 0.038) and with ER negativity than with ER positivity (P = 0.015). Triple-negative cancers showed a higher mean k(ep) than the luminal type (P = 0.015).
Breast cancers with higher K(trans) and k(ep) , or lower v(e) , had poor prognostic factors and were often of the triple-negative subtype.
研究动态对比增强（DCE）磁共振成像（MRI）获得的灌注参数与乳腺癌的预后因素和免疫组织化学亚型之间是否存在相关性。
对 70 例浸润性导管癌进行 DCE-MRI 后处理，获取定量参数（K(trans)、k(ep)、v(e)）。分析参数与肿瘤大小、腋窝淋巴结状态、组织学分级、核分级、雌激素受体（ER）、孕激素受体（PR）、Ki-67、p53、bcl-2、人表皮生长因子受体 2（HER2）表达及分为 luminal（ER 或 PR 阳性）、三阴性（ER 或 PR 阴性、HER2 阴性）和 HER2（ER 和 PR 阴性、HER2 过表达）亚型之间的相关性。
组织学分级高的肿瘤 K(trans)均值高于组织学分级低的肿瘤（P=0.007），核分级高的肿瘤 K(trans)均值高于核分级低的肿瘤（P=0.002），ER 阴性的肿瘤 K(trans)均值高于 ER 阳性的肿瘤（P=0.056）。组织学分级高的肿瘤 k(ep)均值高于组织学分级低的肿瘤（P=0.005），核分级高的肿瘤 k(ep)均值高于核分级低的肿瘤（P=0.001），ER 阴性的肿瘤 k(ep)均值高于 ER 阳性的肿瘤（P=0.043）。组织学分级高的肿瘤 v(e)均值低于组织学分级低的肿瘤（P=0.038），ER 阴性的肿瘤 v(e)均值低于 ER 阳性的肿瘤（P=0.015）。三阴性乳腺癌的 k(ep)均值高于 luminal 型（P=0.015）。
K(trans)和 k(ep)较高、v(e)较低的乳腺癌具有不良预后因素，且常为三阴性亚型。
