Xue Bailin, Yao Zhihong, Yu Rongmin
College of Pharmacy, Jinan University, Guangzhou 510632, China.
Zhongguo Zhong Yao Za Zhi. 2011 Dec;36(23):3366-70.
Hand-foot-and-mouth disease is caused by intestinal virus infection. The viruses coxsackie A16 (CA16) and enterovirus 71 (EV71) are the main pathogens. Between them, the virus EV71 is more dangerous and easier to cause serious complications, which leads to death or disability. Currently, there are no effective antiviral drugs to treat EV71 infection. Therefore, developing an effective drug against EV71 virus activity is significant. It has a huge potency of screening the anti-EV71 components and developing the new drugs from the abundant traditional Chinese medicines (TCMs). Meanwhile, since hand-foot-and-mouth disease spread in Shanghai in 1981, a growing number of reports on TCMs treatment in clinic have been published. In addition, most of treatments with various ways are effective, which play a positive role on improving clinic treatment and controlling diseases. Moreover, special clinic advantages and features of TCMs were obviously shown.
手足口病由肠道病毒感染引起。柯萨奇病毒A16（CA16）和肠道病毒71型（EV71）是主要病原体。其中，EV71病毒更危险，更容易引发严重并发症，导致死亡或残疾。目前，尚无有效的抗病毒药物治疗EV71感染。因此，开发一种针对EV71病毒活性的有效药物具有重要意义。从丰富的传统中药中筛选抗EV71成分并开发新药具有巨大潜力。同时，自1981年手足口病在上海传播以来，临床上越来越多关于中药治疗的报道被发表。此外，多种方式的治疗大多有效，对改善临床治疗和控制疾病起到了积极作用。而且，中药独特的临床优势和特点也明显显现出来。
