Mathiesen L R, Fauerholdt L, Møller A M, Aldershvile J, Dietrichson O, Hardt F, Nielsen J O, Skinhøj P
Gastroenterology. 1979 Oct;77(4 Pt 1):623-8.
Immunofluorescence studies for hepatitis A virus and hepatitis B surface and core antigen were performed on liver biopsies from 48 patients with acute viral hepatitis. Hepatitis A virus was detected in 11 out of 17 patients with type A hepatitis and was not found in patients with type B or non-A non-B hepatitis. Hepatitis B surface and core antigens were detected in 2, hepatitis B core antigen alone in 1, and hepatitis B surface antigen alone in 4 out of 24 patients with type B hepatitis. Neither hepatitis B surface nor core antigen were found in patients with type A or non-A non-B hepatitis. One patient with both type A and B hepatitis were all negative for hepatitis A virus, and hepatitis B surface and core antigens. Immunofluorescence examination for hepatitis A virus in human liver biopsies appears to be a sensitive and specific technique and might be valuable in the search for possible chronic carriers of hepatitis A virus.
对48例急性病毒性肝炎患者的肝活检组织进行了甲型肝炎病毒及乙型肝炎表面抗原和核心抗原的免疫荧光研究。在17例甲型肝炎患者中，11例检测到甲型肝炎病毒，而在乙型肝炎或非甲非乙型肝炎患者中未检测到。在24例乙型肝炎患者中，2例检测到乙型肝炎表面抗原和核心抗原，1例仅检测到乙型肝炎核心抗原，4例仅检测到乙型肝炎表面抗原。在甲型肝炎或非甲非乙型肝炎患者中均未检测到乙型肝炎表面抗原和核心抗原。1例同时患有甲型和乙型肝炎的患者，甲型肝炎病毒、乙型肝炎表面抗原和核心抗原检测均为阴性。人肝活检组织中甲型肝炎病毒的免疫荧光检查似乎是一种敏感且特异的技术，在寻找甲型肝炎病毒可能的慢性携带者方面可能具有重要价值。
