Tajika Y, Reifenberger G, Kiwit J C, Wechsler W
Department of Neuropathology, Heinrich-Heine-University of Düsseldorf, Federal Republic of Germany.
Acta Neurochir (Wien). 1990;105(1-2):50-5. doi: 10.1007/BF01664858.
Metastatic spreading of carcinoma into a pre-existing cerebral glioma is extremely rare and only a few well-documented cases have been reported in the literature. Here we report a 53-year-old man who at the age 49 was first operated on for a frontal astrocytoma (WHO-grade II). This tumour was completely resected and no post-operative radio- or chemotherapy was applied. About five years later the patient presented again with a large partially cystic space-occupying lesion at the same site, which pre-operatively appeared as a recurrence of the astrocytoma. Histologically, however, this tumour proved to be a metastatic adenocarcinoma into a recurrent astrocytoma. Further clinical examinations revealed a bronchial carcinoma as the primary lesion responsible for this unusual metastatis. The clinical and neuropathological findings of this interesting case including immunohistochemistry are presented and discussed.
癌转移至先前存在的脑胶质瘤极为罕见，文献中仅报道了少数有充分记录的病例。本文报告一名53岁男性，49岁时首次因额叶星形细胞瘤（世界卫生组织二级）接受手术。该肿瘤被完全切除，术后未进行放疗或化疗。大约五年后，患者再次在同一部位出现一个大的部分囊性占位性病变，术前表现为星形细胞瘤复发。然而，组织学检查显示该肿瘤为转移至复发性星形细胞瘤的腺癌。进一步的临床检查发现支气管癌是导致这种不寻常转移的原发病变。本文展示并讨论了该有趣病例的临床和神经病理学发现，包括免疫组织化学结果。
