Sperb R A, Arnold W, Gebbers J O
Pathologisches Institut, Kantonsspital Luzern.
Pathologe. 1996 Sep;17(5):385-90. doi: 10.1007/s002920050177.
In the rare event of cancer-to-cancer metastasis, one malignant neoplasm spreads to a second carcinoma. To date, 42 such cases have been published in the English- and German-language literature. We report two additional patients, each with metastatic bronchial cancer present in a renal carcinoma. In addition to immunohistochemical examinations, we performed in situ DNA image cytometry of histologic preparations as a novel analytical technique to differentiate metastatic tissue from the host tumor. In both cases DNA histograms of metastatic tumor resembled those of the primary malignancy but were clearly dissimilar to the host tumor. In 70% of previously reported cases renal carcinoma was the host tumor while in 50%, cancer of the lung was the most frequent donor tumor.
在极为罕见的癌至癌转移情况下，一种恶性肿瘤扩散至另一种癌。迄今为止，英文和德文文献中已发表了42例此类病例。我们报告另外两名患者，他们的肾癌中均出现了转移性支气管癌。除免疫组化检查外，我们还对组织学标本进行了原位DNA图像细胞术，作为一种新的分析技术，以区分转移组织与宿主肿瘤。在这两个病例中，转移瘤的DNA直方图与原发性恶性肿瘤相似，但与宿主肿瘤明显不同。在先前报道的病例中，70%以肾癌作为宿主肿瘤，而在50%的病例中，肺癌是最常见的供体肿瘤。
