Liu Yin, Zhang Deping
Department of Respiratory Medicine, Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Asian Pac J Cancer Prev. 2011;12(11):3091-5.
NAD(P)H: quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein that catalyzes the two- electron reduction of quinoid compounds into hydroquinones. A single base substitution (C?T) polymorphism at 609 in the NQO1 gene reduces quinone reductase activity. Published data on the association between NQO1 C609T polymorphism and lung cancer risk are conflicting.
To derive a more precise estimation of the relationship, a meta-analysis was performed.
A total of 23 studies including 5,575 cases and 9,132 controls were assessed. The pooled result showed that the NQO1 polymorphism was not associated with a clear increased risk of lung cancer (OR = 1.009, 95% CI: 0.943-1.078; P heterogeneity=0.049). In the subgroup analysis by ethnicity, no clear increased risk was found among Asians for TT/CT versus CC (OR = 1.005; 95% CI = 0.890-1.135; P heterogeneity=0.024). However, the TT and CT genotypes combined were associated with significantly increased risk of lung cancer in Chinese (OR = 1.237, 95% CI: 1.029-1.486; P heterogeneity=0.061) among whom the variant allele is common. The variant genotype of NQO1 was also associated with modestly increased risk of lung cancer among white populations (OR = 1.017, 95% CI: 0.936-1.105; P heterogeneity=0.101). However, no significant association was found in Africans with all genetic models.
Our meta-analysis suggests that the variant NQO1 C609T genotype may affect individual susceptibility to lung cancer. This meta- analysis suggests that the NQO1 609T allele is a low penetrant risk factor for developing lung cancer in Chinese.
NAD(P)H：醌氧化还原酶1（NQO1）是一种胞质黄素蛋白，可催化醌类化合物双电子还原为氢醌。NQO1基因609位点的单碱基替换（C→T）多态性会降低醌还原酶活性。关于NQO1 C609T多态性与肺癌风险之间关联的已发表数据相互矛盾。
为更精确地评估二者关系，进行了一项荟萃分析。
共评估了23项研究，包括5575例病例和9132例对照。汇总结果显示，NQO1多态性与肺癌风险明显增加无关（OR = 1.009，95%CI：0.943 - 1.078；P异质性 = 0.049）。在按种族进行的亚组分析中，亚洲人中TT/CT与CC相比，未发现肺癌风险明显增加（OR = 1.005；95%CI = 0.890 - 1.135；P异质性 = 0.024）。然而，在中国人群中，TT和CT基因型合并与肺癌风险显著增加相关（OR = 1.237，95%CI：1.029 - 1.486；P异质性 = 0.061），其中变异等位基因较为常见。NQO1的变异基因型在白种人群中也与肺癌风险适度增加相关（OR = 1.017，95%CI：0.936 - 1.105；P异质性 = 0.101）。然而，在非洲人群的所有遗传模型中均未发现显著关联。
我们的荟萃分析表明，NQO1 C609T变异基因型可能影响个体对肺癌的易感性。该荟萃分析表明，NQO1 609T等位基因是中国人群患肺癌的低外显率风险因素。
