Wang Yongbing, Zhang Genfu, Luo Yunbao
Department of General Surgery, Shanghai Pudong New Area People's Hospital, Shanghai, 201299, China,
Tumour Biol. 2013 Dec;34(6):4027-32. doi: 10.1007/s13277-013-0993-7. Epub 2013 Jul 28.
quinone oxidoreductase 1 (NQO1) is a cytosolic enzyme, and the NQO1 C609T polymorphism is associated with the enzymatic activity of NQO1. Many studies were performed to assess the association between NQO1 C609T polymorphism and colorectal cancer risk, but no consensus was available up to now. We conducted a meta-analysis to examine the association between NQO1 C609T polymorphism and colorectal cancer risk, and the pooled odds ratios (OR) with their 95% confidence intervals (95% CI) were used to assess the association. Finally, 12 studies involving 4,026 cases and 4,855 controls were included into the meta-analysis. Overall, there was an obvious association between NQO1 C609T polymorphism and colorectal cancer risk (T versus C: OR = 1.28, 95% CI 1.08-1.51, P = 0.005; TT versus CC: OR = 1.60, 95% CI 1.10-2.33, P = 0.015; TT/CT versus CC: OR = 1.36, 95% CI 1.09-1.69, P = 0.006; TT versus CT/CC: OR = 1.37, 95% CI 1.05-1.80, P = 0.022). Subgroup analysis by ethnicity showed that the association was obvious in both Caucasians and Asians. Therefore, the meta-analysis provides strong evidence for the association between NQO1 C609T polymorphism and colorectal cancer risk, and the T allele of NQO1 C609T polymorphism is an important risk factor of colorectal cancer.
醌氧化还原酶1（NQO1）是一种胞质酶，NQO1 C609T多态性与NQO1的酶活性相关。许多研究旨在评估NQO1 C609T多态性与结直肠癌风险之间的关联，但截至目前尚未达成共识。我们进行了一项荟萃分析，以检验NQO1 C609T多态性与结直肠癌风险之间的关联，并使用合并优势比（OR）及其95%置信区间（95%CI）来评估这种关联。最终，12项研究（涉及4026例病例和4855例对照）被纳入荟萃分析。总体而言，NQO1 C609T多态性与结直肠癌风险之间存在明显关联（T与C相比：OR = 1.28，95%CI 1.08 - 1.51，P = 0.005；TT与CC相比：OR = 1.60，95%CI 1.10 - 2.33，P = 0.015；TT/CT与CC相比：OR = 1.36，95%CI 1.09 - 1.69，P = 0.006；TT与CT/CC相比：OR = 1.37，95%CI 1.05 - 1.80，P = 0.022）。按种族进行的亚组分析表明，在白种人和亚洲人中这种关联均很明显。因此，荟萃分析为NQO1 C609T多态性与结直肠癌风险之间的关联提供了有力证据，且NQO1 C609T多态性的T等位基因是结直肠癌的一个重要风险因素。
