Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.
Gynecol Endocrinol. 2012 Mar;28 Suppl 1:27-32. doi: 10.3109/09513590.2012.651930.
Metabolism is controlled through homeostatic system consisting of central centers, gut hormones, hormones from adipose tissue and the other hormonal axes. This cooperation is based on cross-talk between central and peripheral signals. Among them the hypothalamus plays a crucial role, with interconnected nuclei forming neuronal circuits. Other regions in the brain, such as the brain stem, the endocannabinoid system, the vagal afferents, are also involved in energy balance. The second component is peripheral source of signals--the gastrointestinal tract hormones. Additionally, adipokines from adipose tissue, thyrotropic, gonadotropic and somatotropic axes play a role in energy homeostasis. Knowledge about all components of this neuroendocrine circuit will be helpful in developing novel therapeutic approaches against the metabolic syndrome and its components.
代谢是通过由中枢中心、肠道激素、脂肪组织激素和其他激素轴组成的稳态系统来控制的。这种合作是基于中枢和外周信号之间的串扰。其中，下丘脑起着至关重要的作用，相互连接的核形成神经元回路。大脑的其他区域，如脑干、内源性大麻素系统、迷走传入神经，也参与能量平衡。第二个组成部分是信号的外周来源——胃肠道激素。此外，来自脂肪组织的 adipokines、促甲状腺素、促性腺激素和生长激素轴在能量平衡中也发挥作用。了解这个神经内分泌回路的所有组成部分将有助于开发针对代谢综合征及其成分的新的治疗方法。
