Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Phytochemistry. 2011 Dec;72(17):2197-204. doi: 10.1016/j.phytochem.2011.08.003. Epub 2011 Aug 27.
Three monoterpenoids and two triterpenoids were isolated from Abies nephrolepis together with 53 known terpenoids. The structures of the compounds were established by 1D and 2D NMR spectroscopy. The absolute configuration of 3-hydroxycamphane-2-carboxylic acid was established as (1S,2R,3S,4R) by Cu-Kα X-ray crystallography. All 58 isolates were tested for cytotoxic activity against four tumor cells viz. A549 (human lung adenocarcinoma), Colo205 (colon adenocarcinoma), QGY-7703 (human hepatoma) and THP-1 (human monocytic leukemia). α-Cadinol exhibited the best effects on A549, Colo205 and QGY-7703 with IC(50) values of 8.6, 8.1 and 4.6 μg/mL, respectively.
从冷杉中分离得到了三种单萜和两种三萜，以及 53 种已知萜类化合物。通过 1D 和 2D NMR 光谱确定了化合物的结构。通过 Cu-Kα X 射线晶体学确定了 3-羟基莰烷-2-羧酸的绝对构型为（1S,2R,3S,4R）。对 58 种分离物进行了对四种肿瘤细胞（A549（人肺腺癌）、Colo205（结肠腺癌）、QGY-7703（人肝癌）和 THP-1（人单核白血病））的细胞毒性活性测试。α-杜松醇对 A549、Colo205 和 QGY-7703 的抑制作用最好，IC（50）值分别为 8.6、8.1 和 4.6 μg/mL。
