比优酮 A-C，贯叶连翘中的新五环倍半萜类化合物。

Biyoulactones A-C, new pentacyclic meroterpenoids from Hypericum chinense.

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

出版信息

Org Lett. 2011 Oct 21;13(20):5488-91. doi: 10.1021/ol2021548. Epub 2011 Sep 16.

DOI:10.1021/ol2021548

PMID:21923090

Abstract

Three novel pentacyclic meroterpenoids with a unique dilactone structure containing C-C bonded bi- and tricyclic γ-lactone moieties, biyoulactones A-C (1-3), were isolated from the roots of Hypericum chinense, and their structures were elucidated on the basis of spectroscopic data. The relative and absolute stereochemistry of 1 was assigned by a combination of NOESY and a single crystal X-ray diffraction analysis.

摘要

从贯叶连翘的根部分离得到三个新型五环倍半萜类化合物，具有独特的二内酯结构，包含 C-C 键合的双和三环γ-内酯部分，分别命名为比尤拉醇 A-C（1-3）。基于光谱数据阐明了它们的结构。通过 NOESY 和单晶 X 射线衍射分析的组合确定了 1 的相对和绝对立体化学。