Fleming Tom P, Lucas Emma S, Watkins Adam J, Eckert Judith J
School of Biological Sciences, University of Southampton, Mailpoint 840, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.
Reprod Fertil Dev. 2011;24(1):35-44. doi: 10.1071/RD11905.
Maternal periconceptional (PC) nutrition, coupled with maternal physiological condition, can impact on reproductive performance and potential across mammalian species. Oocyte quality and embryo development are affected adversely by either nutrient restriction or excess. Moreover, the quality of maternal PC nutrition can have lasting effects through fetal development and postnatally into adulthood. Chronic disease, notably cardiovascular and metabolic disease, and abnormal behaviour have been identified in adult offspring in small and large animal models of PC nutrient restriction. These long-term effects associate with compensatory responses that begin from the time of early embryo development. This review assesses the field of PC nutrition in vivo on short- and long-term developmental consequences in rodent and ruminant models and considers the implications for human health.
孕期前（PC）营养与母体生理状况相结合，会影响所有哺乳动物的生殖性能和潜力。营养限制或营养过剩都会对卵母细胞质量和胚胎发育产生不利影响。此外，孕期前母体营养质量可通过胎儿发育并持续到出生后直至成年产生持久影响。在孕期前营养限制的大小动物模型中，已在成年后代中发现了慢性疾病，尤其是心血管和代谢疾病，以及异常行为。这些长期影响与从早期胚胎发育时就开始的代偿反应有关。本综述评估了孕期前体内营养领域对啮齿动物和反刍动物模型短期和长期发育后果的影响，并探讨了其对人类健康的意义。
