Calne D B, Eisen A
Belzberg Laboratory of Clinical Neuroscience, Department of Medicine, University of British Columbia, Vancouver, Canada.
Adv Neurol. 1990;53:355-60.
The cause of neurodegenerative disease is considered. For Alzheimer's disease, Parkinson's disease, and motoneuron disease, accumulating evidence over the last 3 years indicates that (a) the usual etiological mechanisms involve a subclinical lesion which kills some neurons and reduces the life expectation of their surviving neighbors, and (b) there may be more than one cause for each of the idiopathic syndromes now termed AD, PD, and MND.
本文探讨了神经退行性疾病的病因。对于阿尔茨海默病、帕金森病和运动神经元病，过去三年积累的证据表明：（a）常见的病因机制涉及一种亚临床病变，这种病变会杀死一些神经元并缩短其存活邻居的预期寿命；（b）目前称为AD、PD和MND的每种特发性综合征可能有多种病因。
