Department of Anaesthesia, G. S. Medical College and K E M Hospital, Mumbai, India.
J Anesth. 2012 Jun;26(3):346-50. doi: 10.1007/s00540-012-1341-6. Epub 2012 Mar 1.
Midazolam premedication administered by the intranasal route is noninvasive with good bioavailability. Atomised intranasal midazolam spray ensures accurate drug dosage and better patient acceptability, with rapid onset of action and virtually complete absorption.
Sixty pediatric patients scheduled for elective surgeries were administered atomised intranasal midazolam. Two doses of midazolam, of 0.2 and 0.3 mg/kg, were compared. Children were observed for achieving satisfactory sedation and separation scores, and face mask acceptance.
At 10 and 20 min of nasal administration, 70 and 76% of the children, respectively, in the 0.3 mg/kg dose group, while 40 and 63% of the children, respectively, in the 0.2 mg/kg group were adequately sedated. Similarly, at 10 and 20 min after administration, 66.6 and 73.3% of children, respectively, in the 0.3 mg/kg group, and 30 and 60% in the 0.2 mg/kg group were easily separated from their parents. With regard to face mask acceptance, 33.3% of patients in the 0.3 mg/kg group and 16.6% in the 0.2 mg/kg group accepted the mask easily.
Atomised midazolam at 0.3 mg/kg is safe, and achieves faster sedation and better separation scores as compared to 0.2 mg/kg.
经鼻途径给予咪达唑仑预处理是非侵入性的，具有良好的生物利用度。雾化鼻内咪达唑仑喷雾可确保准确的药物剂量和更好的患者可接受性，起效迅速，几乎完全吸收。
60 名计划接受择期手术的儿科患者给予雾化鼻内咪达唑仑。比较了 0.2 和 0.3mg/kg 两个剂量的咪达唑仑。观察儿童达到满意的镇静和分离评分，以及面罩接受程度。
在鼻内给药 10 和 20 分钟时，分别有 70%和 76%的 0.3mg/kg 剂量组儿童，以及 40%和 63%的 0.2mg/kg 剂量组儿童镇静充分。同样，在给药后 10 和 20 分钟，分别有 66.6%和 73.3%的 0.3mg/kg 剂量组儿童，以及 30%和 60%的 0.2mg/kg 剂量组儿童容易与父母分离。关于面罩接受程度，0.3mg/kg 剂量组 33.3%的患者和 0.2mg/kg 剂量组 16.6%的患者容易接受面罩。
与 0.2mg/kg 相比，0.3mg/kg 的雾化咪达唑仑更安全，可更快达到镇静效果，分离评分更好。
