Gohji K, Matsumoto O, Kamidono S
Department of Urology, Kobe University School of Medicine.
Hinyokika Kiyo. 1990 Jun;36(6):677-81.
A case of asynchronous bilateral renal cell carcinoma with pancreatic metastasis is described. Left nephrectomy and tumorectomy in the right kidney were performed. Solitary metastasis to the pancreas without symptoms was treated by distal pancreatectomy with tumor and splenectomy. Although bilateral renal cell carcinomas were histologically renal cell carcinoma (clear cell subtype, grade 2), the resected pancreatic tumor was renal cell carcinoma with sarcomatoid change. Therefore, the metastatic tumor had a more malignant potential than the primary tumor. The pancreatic metastasis was seen at 6 years 10 months and 2 years 6 months after left nephrectomy and enucleation of the right renal tumors, respectively. The patient is alive without disease and is being treated by alpha-interferon for 12 months after distal pancreatectomy. A careful long-term follow-up of the patient with renal cell carcinoma seems to be necessary.
本文描述了一例伴有胰腺转移的异步双侧肾细胞癌病例。实施了左肾切除术及右肾肿瘤切除术。对无症状的孤立性胰腺转移灶行远端胰腺肿瘤切除术及脾切除术。尽管双侧肾细胞癌在组织学上均为肾细胞癌（透明细胞亚型，2级），但切除的胰腺肿瘤为伴有肉瘤样变的肾细胞癌。因此，转移瘤比原发肿瘤具有更高的恶性潜能。胰腺转移分别在左肾切除术后6年10个月及右肾肿瘤剜除术后2年6个月被发现。患者无病存活，在远端胰腺切除术后接受了12个月的α干扰素治疗。对肾细胞癌患者进行仔细的长期随访似乎很有必要。
