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用于糖尿病肢体挽救的永久性抗生素浸渍髓内钉：一例报告及文献综述

Permanent antibiotic impregnated intramedullary nail in diabetic limb salvage: a case report and literature review.

作者信息

Woods Jason B, Lowery Nicholas J, Burns Patrick R

机构信息

Podiatric Medicine and Surgery Residency Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

出版信息

Diabet Foot Ankle. 2012;3. doi: 10.3402/dfa.v3i0.11908. Epub 2012 Feb 1.

DOI:10.3402/dfa.v3i0.11908
PMID:22396833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3284274/
Abstract

Managing complications after attempted hind foot and ankle arthrodesis with intramedullary nail fixation is a challenge. This situation becomes more problematic in the patient with diabetes mellitus and multiple comorbidities. Infection and subsequent osteomyelitis can be a devastating, limb threatening complication associated with these procedures. The surgeon must manage both the infectious process and the skeletal instability concurrently. This article provides a literature review and detailed management strategies for a modified technique of employing antibiotic impregnated polymethylmethacrylate-coated intramedullary nailing.

摘要

处理尝试使用髓内钉固定进行后足和踝关节融合术后的并发症是一项挑战。对于患有糖尿病和多种合并症的患者，这种情况会变得更棘手。感染及随后的骨髓炎可能是与这些手术相关的一种毁灭性的、威胁肢体的并发症。外科医生必须同时处理感染过程和骨骼不稳定问题。本文提供了一篇文献综述以及关于采用抗生素浸渍聚甲基丙烯酸甲酯涂层髓内钉固定的改良技术的详细管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c095/3284274/cb52d9b83d65/DFA-3-11908-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c095/3284274/cb52d9b83d65/DFA-3-11908-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c095/3284274/cb52d9b83d65/DFA-3-11908-g001.jpg

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本文引用的文献

1
Antibiotic-coated nails in orthopedic and trauma surgery: state of the art.骨科和创伤外科中的抗生素涂层钉：最新技术。
Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1 Suppl 2):125-8. doi: 10.1177/03946320110241S223.
2
A simple method for fashioning an antibiotic cement-coated interlocking intramedullary nail.一种制作抗生素骨水泥涂层交锁髓内钉的简易方法。
Am J Orthop (Belle Mead NJ). 2010 Jan;39(1):18-21.
3
Postoperative infection rates in foot and ankle surgery: a comparison of patients with and without diabetes mellitus.
Antibiotic cement coating in orthopedic surgery: a systematic review of reported clinical techniques.
骨科手术中的抗生素水泥涂层：报告的临床技术的系统评价。
J Orthop Traumatol. 2021 Dec 23;22(1):56. doi: 10.1186/s10195-021-00614-7.
4
Fast-resorbable antibiotic-loaded hydrogel coating to reduce post-surgical infection after internal osteosynthesis: a multicenter randomized controlled trial.可快速吸收的载抗生素水凝胶涂层减少内固定术后手术部位感染：一项多中心随机对照试验
J Orthop Traumatol. 2017 Jun;18(2):159-169. doi: 10.1007/s10195-017-0442-2. Epub 2017 Feb 2.
足部和踝关节手术后的感染率：糖尿病患者与非糖尿病患者的比较。
J Bone Joint Surg Am. 2010 Feb;92(2):287-95. doi: 10.2106/JBJS.I.00080.
4
Treatment of long bone osteomyelitis with a mechanically stable intramedullar antibiotic dispenser: nineteen consecutive cases with a minimum of 12 months follow-up.使用机械稳定的髓内抗生素给药装置治疗长骨骨髓炎：连续19例，至少随访12个月。
J Trauma. 2008 Dec;65(6):1416-20. doi: 10.1097/TA.0b013e31818c6a09.
5
Antibiotic cement-coated interlocking nail for the treatment of infected nonunions and segmental bone defects.抗生素骨水泥涂层交锁髓内钉治疗感染性骨不连和节段性骨缺损
J Orthop Trauma. 2007 Apr;21(4):258-68. doi: 10.1097/BOT.0b013e31803ea9e6.
6
Use of antibiotic cement rod to treat intramedullary infection after nailing: preliminary study in 19 patients.使用抗生素骨水泥棒治疗髓内钉固定术后髓内感染：19例患者的初步研究
Arch Orthop Trauma Surg. 2007 Dec;127(10):945-51. doi: 10.1007/s00402-007-0315-x. Epub 2007 Mar 27.
7
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J Foot Ankle Surg. 2006 Mar-Apr;45(2):98-106. doi: 10.1053/j.jfas.2005.12.001.
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Chronic posttraumatic osteomyelitis and infected nonunion of the tibia: current management concepts.慢性创伤后骨髓炎及胫骨感染性骨不连：当前的治疗理念
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The antibiotic cement nail for infection after tibial nailing.用于胫骨髓内钉固定术后感染的抗生素骨水泥钉
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Intramedullary infections treated with antibiotic cement rods: preliminary results in nine cases.采用抗生素骨水泥棒治疗的髓内感染：9例初步结果
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