Uzun Suzana, Kozumplik Oliver, Folnegović-Smalc Vera
Vrapce Psychiatric Hospital, Zagreb, Croatia.
Coll Antropol. 2011 Dec;35(4):1333-7.
The review focuses on current data on Alzhemier's dementia, a clinical syndrom characterised with acquired deterioration of cognitive functioning and emotional capacities, which impaires everyday activity and quality of life. Alzheimer's dementia is the most common type of dementia in clinical surveys. The diagnosis of Alzheimer's dementia is primarily based on symptoms and signs and memory impairment is clinically most significant. Cholinesterase inhibitors -donepezil, rivastigmine and galantamine are considered to be the first line pharmacotherapy for mild to moderate Alzheimer's disease. Currently, no effective pharmacologic interventions have been researched enough to support their use in prevention of Alzheimer's dementia. Studies suggest that healthy lifestyle, ongoing education, regular physical activity, and cholesterol control, play a role in prevention of Alzheimer's dementia.
这篇综述聚焦于阿尔茨海默病性痴呆的当前数据，这是一种临床综合征，其特征为认知功能和情感能力的后天性衰退，会损害日常活动和生活质量。在临床调查中，阿尔茨海默病性痴呆是最常见的痴呆类型。阿尔茨海默病性痴呆的诊断主要基于症状和体征，其中记忆障碍在临床上最为显著。胆碱酯酶抑制剂——多奈哌齐、卡巴拉汀和加兰他敏被认为是轻至中度阿尔茨海默病的一线药物治疗方法。目前，尚未对足够有效的药物干预措施进行研究以支持其用于预防阿尔茨海默病性痴呆。研究表明，健康的生活方式、持续学习、规律的体育活动和胆固醇控制在预防阿尔茨海默病性痴呆中发挥作用。
