Lutz J, Tesar R
School of Nursing, University of Texas, Austin 78701.
Am J Clin Nutr. 1990 Nov;52(5):872-7. doi: 10.1093/ajcn/52.5.872.
Bone mineral density (BMD) of the lumbar spine (L1-L4) and femur (femoral neck, Ward's triangle, and trochanter) was measured in 37 healthy, white mother-daughter pairs by dual-photon absorptiometry. Mothers and daughters were aged 52 +/- 7 and 25 +/- 4 y (mean +/- SD), respectively. Three-day dietary intakes were evaluated. Significant correlations between mother-daughter pairs for BMD of all lumbar and femoral areas [except for L2 (r = 0.26, P = 0.054)] indicated familial resemblances in bone mineralization. Total calcium intake was significantly correlated with three BMD values for the daughters (L2, femoral neck, and trochanter) but not for the mothers. When mothers were classified as pre- (n = 20) or postmenopausal (n = 17), correlation coefficients for BMD were higher for premenopausal mothers and their daughters and lower for postmenopausal mothers and their daughters, except for the trochanter. The results suggest that the nature of inheritance of bone mass of women may have at least two components, one influencing the level of peak bone mass and one related to bone loss at menopause.
采用双能光子吸收法对37对健康的白人母女进行腰椎（L1 - L4）和股骨（股骨颈、沃德三角区和大转子）骨密度（BMD）测量。母亲和女儿的年龄分别为52±7岁和25±4岁（均值±标准差）。评估了她们三天的饮食摄入量。所有腰椎和股骨区域的母女间骨密度存在显著相关性[L2除外（r = 0.26，P = 0.054）]，表明骨矿化存在家族相似性。女儿的总钙摄入量与三个骨密度值（L2、股骨颈和大转子）显著相关，但母亲的总钙摄入量与骨密度值无显著相关性。将母亲分为绝经前（n = 20）或绝经后（n = 17），除大转子外，绝经前母亲及其女儿的骨密度相关系数高于绝经后母亲及其女儿。结果表明，女性骨量的遗传性质可能至少有两个组成部分，一个影响峰值骨量水平，另一个与绝经后骨质流失有关。
