黑色素瘤患者的远隔效应的免疫相关性。
Immunologic correlates of the abscopal effect in a patient with melanoma.
机构信息
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
出版信息
N Engl J Med. 2012 Mar 8;366(10):925-31. doi: 10.1056/NEJMoa1112824.
Abstract
The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.).
摘要
远隔效应是一种现象，即局部放射治疗与照射部位远处转移癌的消退有关。远隔效应可能是通过免疫系统的激活介导的。Ipilimumab 是一种单克隆抗体，可抑制 T 细胞上的免疫检查点，细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）。我们报告了一例黑色素瘤患者接受 Ipilimumab 和放射治疗后出现远隔效应的病例。注意到时间关联：肿瘤缩小，对癌症睾丸抗原 NY-ESO-1 产生抗体反应，外周血免疫细胞发生变化，以及放射治疗后对其他抗原的抗体反应增加。（由美国国立卫生研究院等资助）。
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