Maclure K M, Hayes K C, Colditz G A, Stampfer M J, Willett W C
Department of Epidemiology, Harvard School of Public Health, Boston, MA.
Am J Clin Nutr. 1990 Nov;52(5):916-22. doi: 10.1093/ajcn/52.5.916.
In 1980, 88,837 women aged 34-59 y completed a semiquantitative food frequency questionnaire and were followed for 4 y. Four hundred thirty-three women reported a cholecystectomy for recent cholecystitis, and 179 reported unremoved, newly symptomatic gallstones diagnosed by ultrasound or x ray. Among the 59,306 women with Quetelet's index of relative weight less than 25 kg/m2, inverse associations were observed between intakes of vegetable fat and vegetable protein and the risk of reportedly symptomatic gallastones, after adjusting for age, Quetelet's index in 1980, weight change between 1976 and 1980, energy intake, and alcohol intake. The relative risk in the highest quintile of vegetable fat intake, as compared with the lowest quintile, was 0.6 [95% confidence interval (CI), 0.4-0.9], and the corresponding relative risk for vegetable protein intake was 0.7 (95% CI, 0.6-0.9). No significant associations were found with energy-adjusted intakes of cholesterol, animal fat, animal protein, carbohydrate, or sucrose.
1980年，88837名年龄在34至59岁之间的女性完成了一份半定量食物频率问卷，并接受了4年的随访。433名女性报告因近期胆囊炎进行了胆囊切除术，179名报告通过超声或X光诊断出有未切除的新发有症状胆结石。在体重身高指数（Quetelet指数）低于25kg/m²的59306名女性中，在调整了年龄、1980年的Quetelet指数、1976年至1980年的体重变化、能量摄入和酒精摄入后，观察到植物脂肪和植物蛋白的摄入量与据报告有症状胆结石的风险呈负相关。与最低五分位数相比，植物脂肪摄入量最高五分位数的相对风险为0.6[95%置信区间（CI），0.4 - 0.9]，植物蛋白摄入量的相应相对风险为0.7（95%CI，0.6 - 0.9）。未发现胆固醇、动物脂肪、动物蛋白、碳水化合物或蔗糖的能量调整摄入量有显著关联。
