持续性病毒感染中的白细胞细胞毒性：感染马传染性贫血病毒的马匹存在直接细胞毒性但不存在抗体依赖性细胞毒性。
Leukocyte cytotoxicity in a persistent virus infection: presence of direct cytotoxicity but absence of antibody-dependent cellular cytotoxicity in horses infected with equine infectious anemia virus.
作者信息
Fujimiya Y, Perryman L E, Crawford T B
出版信息
Infect Immun. 1979 Jun;24(3):628-36. doi: 10.1128/iai.24.3.628-636.1979.
Abstract
Antibody-dependent cellular cytotoxicity and direct cytotoxicity assays were performed with equine infectious anemia virus-infected target cells, equine leukocytes, and equine anti-equine infectious anemia virus antibody to determine whether these mechanisms play a role in controlling viral replication in equine infectious anemia. Direct cytotoxicity was observed by using peripheral blood mononuclear cells from 7 of 10 infected horses. Antibody-dependent cellular cytotoxicity was not observed. The antibody-dependent cellular cytotoxicity reaction in horses was then studied by using sheep erythrocytes and trinitrophenylated sheep erythrocytes as target cells. Lysis of these target cells was mediated by neutrophils, monocytes, and lymphocytes. The reaction was activated by antibody of the immunoglobulin G class but not by immunoglobulin G(T). Furthermore, immunoglobulin G(T) efficiently inhibited immunoglobulin G in this function.
摘要
使用感染马传染性贫血病毒的靶细胞、马白细胞和马抗马传染性贫血病毒抗体进行抗体依赖性细胞毒性和直接细胞毒性试验，以确定这些机制是否在控制马传染性贫血病毒复制中发挥作用。在10匹受感染马中的7匹中，通过使用外周血单个核细胞观察到了直接细胞毒性。未观察到抗体依赖性细胞毒性。然后，以绵羊红细胞和三硝基苯化绵羊红细胞作为靶细胞，研究了马的抗体依赖性细胞毒性反应。这些靶细胞的裂解由中性粒细胞、单核细胞和淋巴细胞介导。该反应由免疫球蛋白G类抗体激活，但不由免疫球蛋白G(T)激活。此外，免疫球蛋白G(T)在该功能中有效抑制免疫球蛋白G。
相似文献
1
Leukocyte cytotoxicity in a persistent virus infection: presence of direct cytotoxicity but absence of antibody-dependent cellular cytotoxicity in horses infected with equine infectious anemia virus.持续性病毒感染中的白细胞细胞毒性：感染马传染性贫血病毒的马匹存在直接细胞毒性但不存在抗体依赖性细胞毒性。
Infect Immun. 1979 Jun;24(3):628-36. doi: 10.1128/iai.24.3.628-636.1979.
2
Monocyte activation in horses persistently infected with equine infectious anemia virus.持续感染马传染性贫血病毒的马匹中的单核细胞活化
Infect Immun. 1975 Nov;12(5):1219-21. doi: 10.1128/iai.12.5.1219-1221.1975.
3
Control of equine infectious anemia virus is not dependent on ADCC mediating antibodies.马传染性贫血病毒的控制不依赖于介导抗体依赖性细胞毒性的抗体。
Virology. 1997 Apr 14;230(2):275-80. doi: 10.1006/viro.1997.8502.
4
Equine infectious anemia: detection of infections virus-antibody complexes in the serum.马传染性贫血：血清中感染性病毒-抗体复合物的检测
Immunol Commun. 1972;1(6):545-51. doi: 10.3109/08820137209022963.
5
Antigenic stimulation of T lymphocytes in chronic nononcogenic retrovirus infection: equine infectious anemia.慢性非致瘤性逆转录病毒感染中T淋巴细胞的抗原刺激：马传染性贫血
Infect Immun. 1982 Apr;36(1):38-46. doi: 10.1128/iai.36.1.38-46.1982.
6
Frequency of memory cytotoxic T lymphocytes to equine infectious anemia virus proteins in blood from carrier horses.携带马传染性贫血病毒的马匹血液中针对该病毒蛋白的记忆性细胞毒性T淋巴细胞的频率
Virology. 1997 Nov 10;238(1):85-93. doi: 10.1006/viro.1997.8795.
7
Preparation of hemagglutinating antigen of equine infectious anemia virus from infected equine leukocyte cultures.从感染马白细胞培养物中制备马传染性贫血病毒血凝抗原
Natl Inst Anim Health Q (Tokyo). 1978 Spring;18(1):39-40.
8
Cross-neutralizing and subclass characteristics of antibody from horses with equine infectious anemia virus.马感染马传染性贫血病毒后产生抗体的交叉中和作用及亚类特征
Vet Immunol Immunopathol. 1989 Nov 30;23(1-2):41-9. doi: 10.1016/0165-2427(89)90108-6.
9
Immunology of a persistent retrovirus infection--equine infectious anemia.持续性逆转录病毒感染——马传染性贫血的免疫学
Adv Vet Sci Comp Med. 1979;23:137-59.
10
Cytotoxic T lymphocytes in protection against equine infectious anemia virus.细胞毒性T淋巴细胞在抵抗马传染性贫血病毒中的作用。
Anim Health Res Rev. 2004 Dec;5(2):271-6. doi: 10.1079/ahr200482.
引用本文的文献
1
Equine infectious anemia virus envelope evolution in vivo during persistent infection progressively increases resistance to in vitro serum antibody neutralization as a dominant phenotype.马传染性贫血病毒在持续感染期间体内包膜的进化逐渐增加对体外血清抗体中和的抗性，这是一种主要表型。
J Virol. 2002 Nov;76(21):10588-97. doi: 10.1128/jvi.76.21.10588-10597.2002.
2
Maturation of the cellular and humoral immune responses to persistent infection in horses by equine infectious anemia virus is a complex and lengthy process.马对马传染性贫血病毒持续感染的细胞免疫和体液免疫反应的成熟是一个复杂且漫长的过程。
J Virol. 1997 May;71(5):3840-52. doi: 10.1128/JVI.71.5.3840-3852.1997.
3
Major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes from horses with equine infectious anemia virus recognize Env and Gag/PR proteins.来自感染马传染性贫血病毒马匹的主要组织相容性复合体限制的CD8 + 细胞毒性T淋巴细胞识别Env和Gag/PR蛋白。
J Virol. 1994 Mar;68(3):1459-67. doi: 10.1128/JVI.68.3.1459-1467.1994.
4
The immunopathogenesis of equine infectious anemia virus.马传染性贫血病毒的免疫发病机制。
Virus Res. 1994 May;32(2):111-38. doi: 10.1016/0168-1702(94)90038-8.
5
Antigenic stimulation of T lymphocytes in chronic nononcogenic retrovirus infection: equine infectious anemia.慢性非致瘤性逆转录病毒感染中T淋巴细胞的抗原刺激：马传染性贫血
Infect Immun. 1982 Apr;36(1):38-46. doi: 10.1128/iai.36.1.38-46.1982.
6
Antibody-dependent cell-mediated cytotoxicity in sheep.绵羊中的抗体依赖性细胞介导的细胞毒性作用
Acta Vet Scand. 1985;26(1):105-19. doi: 10.1186/BF03546568.
7
T and B lymphocytes in horses persistently infected with equine infectious anaemia virus.持续感染马传染性贫血病毒的马的T淋巴细胞和B淋巴细胞
Vet Res Commun. 1989;13(1):57-65. doi: 10.1007/BF00366853.
8
Qualitative analyses of cellular immune functions in equine infectious anemia show homology with AIDS.马传染性贫血细胞免疫功能的定性分析显示与艾滋病具有相似性。
Arch Virol. 1989;104(3-4):249-57. doi: 10.1007/BF01315547.
本文引用的文献
1
IMMUNOCHEMICAL STUDIES ON DIPHTHERIA ANTITOXIN. VI. COMPARATIVE STUDIES OF HORSE T AND GAMMA ANTITOXINS IN THE QUANTITATIVE PRECIPITIN REACTION, COMPLEMENT FIXATION, AND INDIRECT HEMAGGLUTINATION OF TANNED AND TOXIN-COATED ERYTHROCYTES.白喉抗毒素的免疫化学研究。VI. 马T和γ抗毒素在定量沉淀反应、补体结合以及鞣酸处理和毒素包被红细胞的间接血凝反应中的比较研究。
Jpn J Exp Med. 1964 Aug;34:167-96.
2
Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes.纯化淋巴细胞对抗体包被的鸡红细胞的接触性溶解作用。
Cell Immunol. 1970 Sep;1(3):300-15. doi: 10.1016/0008-8749(70)90051-1.
3
Equine interferon: absence in equine infectious anemia and kinetics of induction in equine cells.马干扰素：马传染性贫血中缺失及在马细胞中的诱导动力学
J Infect Dis. 1970 Jul-Aug;122(1):10-5. doi: 10.1093/infdis/122.1-2.10.
4
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
5
The complement-fixation reaction in eguine infectious anemia: demonstration of inhibition by IgG (T).马传染性贫血中的补体结合反应：IgG(T)抑制作用的证明
J Immunol. 1971 Dec;107(6):1738-44.
6
Immunodiffusion reaction in equine infectious anemia.马传染性贫血中的免疫扩散反应。
Cornell Vet. 1970 Apr;60(2):330-5.
7
Inhibition of antibody-dependent human lymphocyte-mediated cytotoxicity by immunoglobulin classes, IgG subclasses, and IgG fragments.免疫球蛋白类别、IgG亚类及IgG片段对抗体依赖性人淋巴细胞介导的细胞毒性的抑制作用
Scand J Immunol. 1974;3(1):29-38. doi: 10.1111/j.1365-3083.1974.tb01230.x.
8
Studies of cell-mediated immunity to measles virus by in vitro lymphocyte-mediated cytotoxicity.通过体外淋巴细胞介导的细胞毒性对麻疹病毒的细胞介导免疫研究。
J Infect Dis. 1974 Mar;129(3):233-9. doi: 10.1093/infdis/129.3.233.
9
Lymphocyte mediated cytotoxicity in vitro. Induction and inhibition by humoral antibody and nature of effector cells.体外淋巴细胞介导的细胞毒性。体液抗体的诱导和抑制作用以及效应细胞的性质。
Transplant Rev. 1972;13:91-114. doi: 10.1111/j.1600-065x.1972.tb00061.x.
10
Antibody in the induction and inhibition of lymphocyte cytotoxicity.抗体在淋巴细胞细胞毒性的诱导和抑制中的作用。
Transplant Rev. 1972;13:67-90. doi: 10.1111/j.1600-065x.1972.tb00060.x.
Zotero 插件