Akhtar Naveed, Khan Ali B, Muhammad Said, Ahmed Mahmood, Khan Haji M Shoaib, Rasool Fatima, Saeed Tariq
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Forsch Komplementmed. 2012;19(1):20-5. doi: 10.1159/000335823. Epub 2012 Feb 2.
This study aimed to formulate a water-in-oil emulsion (formulation) of Terminalia chebula versus its vehicle (base) as control, and investigate its effects on skin melanin, skin erythema, skin moisture content, and transepidermal water loss (TEWL).
Base containing no active material, and formulation containing 5% concentrated extract of T. chebula, were developed. Different stability parameters were monitored at 8, 25, and 40 °C, as well as 40 °C + 75% relative humidity, for a period of 4 weeks. It was concluded that the creams remained stable at all storage conditions. Both base and formulation were applied to the cheeks of human volunteers for a period of 8 weeks. Different skin parameters were monitored every week to measure any effect produced by these creams.
Changes in TEWL produced by base and formulation were insignificant (p > 0.05) with respect to time while significant (p ≤ 0.05) with respect to base and formulation. The skin moisture content increased after the application of formulation throughout the study period; this effect was insignificant (p > 0.05) with respect to time while significant (p ≤ 0.05) with respect to base and formulation. Both base and formulation showed insignificant (p > 0.05) effects on skin melanin content with respect to time. Skin erythema was reduced by the formulation. Both base and formulation produced statistically insignificant (p > 0.05) effects on skin sebum.
Both creams were aesthetic with respect to sensory evaluation. T. chebula topical cream showed a positive rejuvenating effect on human skin. Hopefully, this study will encourage more attention towards the research and utilization of herbal medicines.
本研究旨在制备诃子油包水乳液（制剂）并与作为对照的赋形剂（基质）进行比较，研究其对皮肤黑色素、皮肤红斑、皮肤水分含量和经表皮水分流失（TEWL）的影响。
制备不含活性物质的基质以及含有5%诃子浓缩提取物的制剂。在8℃、25℃、40℃以及40℃+75%相对湿度条件下监测不同的稳定性参数，为期4周。结果表明，两种乳膏在所有储存条件下均保持稳定。将基质和制剂均应用于人类志愿者的脸颊，为期8周。每周监测不同的皮肤参数，以测定这些乳膏产生的任何效果。
基质和制剂引起的TEWL变化在时间方面无显著差异（p>0.05），但在基质和制剂之间有显著差异（p≤0.05）。在整个研究期间，应用制剂后皮肤水分含量增加；这种影响在时间方面无显著差异（p>0.05），但在基质和制剂之间有显著差异（p≤0.05）。基质和制剂对皮肤黑色素含量在时间方面均显示无显著影响（p>0.05）。制剂可减轻皮肤红斑。基质和制剂对皮肤皮脂均产生无统计学意义的影响（p>0.05）。
两种乳膏在感官评价方面均具有良好的外观。诃子外用乳膏对人体皮肤显示出积极的焕肤效果。希望本研究将促使更多人关注草药的研究与利用。
