Department of Clinical Medicine, University of Insubria, Varese, Italy.
Semin Thromb Hemost. 2012 Jul;38(5):530-4. doi: 10.1055/s-0032-1305783. Epub 2012 Mar 7.
Venous thromboembolism (VTE) is a multicausal disease. Among minor risk factors, acute infections in general are associated with a transient increased risk of VTE. However, acute hepatitis is usually not reported as a potential risk factor for VTE. Recent studies suggest a possible role of viral hepatitis in the development of VTE and, in particular, of portal vein thrombosis. In this narrative review, we will discuss the possible pathogenetic roles of cytomegalovirus, Epstein-Barr virus, and hepatitis A, B, and C viruses in VTE occurrence, and clinical evidence supporting this hypothesis. The hemostatic state in chronic liver disease and the role of coagulation in liver fibrosis will also be discussed.
静脉血栓栓塞症（VTE）是一种多病因疾病。在较小的危险因素中，一般来说急性感染与 VTE 的一过性风险增加相关。然而，急性肝炎通常不被认为是 VTE 的潜在危险因素。最近的研究表明，病毒性肝炎可能在 VTE 的发生中起作用，特别是在门静脉血栓形成中。在这篇叙述性综述中，我们将讨论巨细胞病毒、EB 病毒以及肝炎 A、B 和 C 病毒在 VTE 发生中的可能发病机制作用，以及支持这一假说的临床证据。慢性肝病的止血状态和凝血在肝纤维化中的作用也将进行讨论。
